.disclaimer[data-astro-cid-2nuxbb3n]{background:#fff8f0;border-left:3px solid #e0952c;border-radius:3px;padding:.7rem 1rem;margin:1rem 0 .4rem;font-size:.86rem;line-height:1.55;color:#5c4a2e}.disclaimer[data-astro-cid-2nuxbb3n] a[data-astro-cid-2nuxbb3n]{color:#b56a12}.methods[data-astro-cid-2nuxbb3n]{margin-top:2rem;background:#f8fafc;border:1px solid #e2e8f0;border-radius:8px;padding:1.1rem 1.3rem}.methods[data-astro-cid-2nuxbb3n] .tier-title[data-astro-cid-2nuxbb3n]{font-size:1.05rem;margin-bottom:.8rem}.method-steps[data-astro-cid-2nuxbb3n]{list-style:none;margin:0;padding:0;display:grid;gap:.7rem}.method-steps[data-astro-cid-2nuxbb3n] li[data-astro-cid-2nuxbb3n]{display:grid;grid-template-columns:8.5rem 1fr;gap:.5rem 1rem;align-items:start}.method-steps[data-astro-cid-2nuxbb3n] .step-k[data-astro-cid-2nuxbb3n]{font-size:.72rem;font-weight:700;text-transform:uppercase;letter-spacing:.03em;color:#0f766e;padding-top:2px}.method-steps[data-astro-cid-2nuxbb3n] div[data-astro-cid-2nuxbb3n]{font-size:.86rem;color:#475569;line-height:1.55}.method-steps[data-astro-cid-2nuxbb3n] a[data-astro-cid-2nuxbb3n]{color:var(--primary-color, #2563eb)}@media(max-width:640px){.method-steps[data-astro-cid-2nuxbb3n] li[data-astro-cid-2nuxbb3n]{grid-template-columns:1fr}}.tier[data-astro-cid-2nuxbb3n]{margin-top:2.5rem}.tier-head[data-astro-cid-2nuxbb3n]{margin-bottom:1rem}.tier-title[data-astro-cid-2nuxbb3n]{font-size:1.25rem;font-weight:700;color:#1e293b;margin:0 0 .25rem}.tier-blurb[data-astro-cid-2nuxbb3n]{font-size:.9rem;color:#64748b;max-width:62rem;margin:0;line-height:1.5}.cards[data-astro-cid-2nuxbb3n]{display:grid;grid-template-columns:repeat(auto-fill,minmax(340px,1fr));gap:1rem}.card-t[data-astro-cid-2nuxbb3n]{background:#fff;border:1px solid #e2e8f0;border-radius:8px;padding:1rem 1.1rem;box-shadow:0 1px 2px #0000000a;display:flex;flex-direction:column}.card-head[data-astro-cid-2nuxbb3n]{display:flex;align-items:baseline;flex-wrap:wrap;gap:.35rem .6rem}.card-sym[data-astro-cid-2nuxbb3n]{font-size:1.15rem;font-weight:700;color:#111827;font-style:italic}.card-name[data-astro-cid-2nuxbb3n]{font-size:.85rem;color:#64748b}.card-tags[data-astro-cid-2nuxbb3n]{display:flex;gap:4px;margin-left:auto;flex-wrap:wrap}.tag[data-astro-cid-2nuxbb3n]{font-size:.68rem;font-family:var(--mono-font, monospace);color:#567;background:#eef2f6;border-radius:4px;padding:1px 6px;white-space:nowrap}.tag[data-astro-cid-2nuxbb3n].surface{background:#e6f7f4;color:#0f766e}.card-headline[data-astro-cid-2nuxbb3n]{font-size:.9rem;font-weight:600;color:#334155;margin:.6rem 0 .7rem;line-height:1.4}.stat-row[data-astro-cid-2nuxbb3n]{display:flex;flex-wrap:wrap;gap:.5rem 1.25rem;padding:.55rem .7rem;margin-bottom:.7rem;background:#f8fafc;border-radius:6px;border:1px solid #eef2f7}.stat[data-astro-cid-2nuxbb3n]{display:flex;flex-direction:column}.stat-k[data-astro-cid-2nuxbb3n]{font-size:.65rem;font-weight:600;text-transform:uppercase;letter-spacing:.03em;color:#94a3b8}.stat-v[data-astro-cid-2nuxbb3n]{font-size:.95rem;font-weight:600;color:#1e293b;font-variant-numeric:tabular-nums}.stat-v[data-astro-cid-2nuxbb3n] .s[data-astro-cid-2nuxbb3n]{font-size:.7rem;font-weight:400;color:#94a3b8}.card-body[data-astro-cid-2nuxbb3n]{display:contents}.card-fields[data-astro-cid-2nuxbb3n]{display:grid;grid-template-columns:auto 1fr;gap:.3rem .7rem;margin:0 0 .7rem}.card-fields[data-astro-cid-2nuxbb3n] dt[data-astro-cid-2nuxbb3n]{font-size:.7rem;font-weight:600;text-transform:uppercase;letter-spacing:.02em;color:#94a3b8;padding-top:2px}.card-fields[data-astro-cid-2nuxbb3n] dd[data-astro-cid-2nuxbb3n]{margin:0;font-size:.85rem;color:#334155;line-height:1.45}.badge[data-astro-cid-2nuxbb3n]{font-size:.72rem;font-weight:600;border-radius:4px;padding:1px 8px;white-space:nowrap}.badge[data-astro-cid-2nuxbb3n].ok{background:#dcfce7;color:#166534}.badge[data-astro-cid-2nuxbb3n].inv{background:#fef3c7;color:#92400e}.badge[data-astro-cid-2nuxbb3n].early{background:#f1f5f9;color:#475569}.badge[data-astro-cid-2nuxbb3n].neg{background:#e2e8f0;color:#334155}.card-caveat[data-astro-cid-2nuxbb3n]{font-size:.82rem;color:#7c2d12;line-height:1.45;margin:auto 0 0;background:#fff7ed;border-left:3px solid #fb923c;border-radius:3px;padding:.5rem .7rem}.caveat-k[data-astro-cid-2nuxbb3n]{font-weight:700;text-transform:uppercase;font-size:.68rem;letter-spacing:.03em;margin-right:.3rem}.card-verdict[data-astro-cid-2nuxbb3n]{font-size:.82rem;color:#334155;line-height:1.5;margin:auto 0 0;background:#f0f6f4;border-left:3px solid #0f766e;border-radius:3px;padding:.5rem .7rem}.verdict-k[data-astro-cid-2nuxbb3n]{font-weight:700;color:#0f766e;font-size:.68rem;text-transform:uppercase;letter-spacing:.03em;margin-right:.3rem}.resource[data-astro-cid-2nuxbb3n]{display:inline-flex;align-items:center;gap:.4rem;align-self:flex-start;margin:0 0 .7rem;padding:.3rem .6rem;text-decoration:none;border:1px solid #dbe4ee;border-radius:6px;background:#f6f9fc;font-size:.8rem;color:#2c6cb0;max-width:100%}.resource[data-astro-cid-2nuxbb3n]:hover{border-color:#2c6cb0;background:#eef4fb}.res-type[data-astro-cid-2nuxbb3n]{font-size:.6rem;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:#64748b;background:#e2e8f0;border-radius:3px;padding:1px 5px}.res-label[data-astro-cid-2nuxbb3n]{overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.res-arrow[data-astro-cid-2nuxbb3n]{color:#94a3b8}.trials[data-astro-cid-2nuxbb3n]{margin:0 0 .7rem;display:flex;flex-direction:column;gap:.35rem}.trials-k[data-astro-cid-2nuxbb3n]{font-size:.65rem;font-weight:700;text-transform:uppercase;letter-spacing:.03em;color:#0f766e}.trial-chip[data-astro-cid-2nuxbb3n]{display:flex;flex-wrap:wrap;align-items:baseline;gap:.15rem .5rem;padding:.35rem .6rem;border:1px solid #cdeae4;border-radius:6px;background:#f2fbf8;text-decoration:none;font-size:.8rem;color:#0f766e}.trial-chip[data-astro-cid-2nuxbb3n]:hover{border-color:#0f766e;background:#e8f7f2}.trial-nct[data-astro-cid-2nuxbb3n]{font-family:var(--mono-font, monospace);font-size:.72rem;font-weight:600}.trial-chip[data-astro-cid-2nuxbb3n]:after{content:"↗";margin-left:auto;color:#5ea99a}.trial-label[data-astro-cid-2nuxbb3n]{font-weight:600;color:#134e4a}.trial-detail[data-astro-cid-2nuxbb3n]{flex-basis:100%;font-size:.72rem;color:#5f7d77}.screen-line[data-astro-cid-2nuxbb3n]{margin:0 0 .7rem;font-size:.76rem;line-height:1.45;color:#64748b;padding-top:.4rem;border-top:1px dashed #e2e8f0}.screen-k[data-astro-cid-2nuxbb3n]{font-weight:700;color:#475569;text-transform:uppercase;font-size:.62rem;letter-spacing:.03em;margin-right:.3rem}.screen-line[data-astro-cid-2nuxbb3n] a[data-astro-cid-2nuxbb3n]{color:var(--primary-color, #2563eb);white-space:nowrap}.bio-screen[data-astro-cid-2nuxbb3n]{display:block;margin-top:.2rem;font-size:.76rem;color:#8695a8}.card-t[data-astro-cid-2nuxbb3n].wide{grid-column:1 / -1;display:grid;grid-template-columns:minmax(0,1fr) minmax(340px,46%);column-gap:1.5rem;align-items:start}.card-t[data-astro-cid-2nuxbb3n].wide .card-head[data-astro-cid-2nuxbb3n]{grid-column:1 / -1}.card-t[data-astro-cid-2nuxbb3n].wide .card-body[data-astro-cid-2nuxbb3n]{display:flex;flex-direction:column}.card-t[data-astro-cid-2nuxbb3n].wide .card-fig[data-astro-cid-2nuxbb3n]{align-self:center}.card-fig[data-astro-cid-2nuxbb3n]{margin:.75rem 0 0;min-width:0}.card-fig[data-astro-cid-2nuxbb3n] img[data-astro-cid-2nuxbb3n]{width:100%;height:auto;display:block;border:1px solid #eef2f7;border-radius:6px;background:#fff}.card-fig[data-astro-cid-2nuxbb3n] figcaption[data-astro-cid-2nuxbb3n]{font-size:.72rem;color:#667;line-height:1.5;margin-top:.5rem}.bio-list[data-astro-cid-2nuxbb3n]{list-style:none;padding:0;margin:0;display:grid;gap:.55rem}.bio-item[data-astro-cid-2nuxbb3n]{display:grid;grid-template-columns:12rem 1fr;gap:.4rem 1rem;align-items:baseline;padding:.55rem .8rem;background:#fff;border:1px solid #e9edf2;border-radius:6px}.bio-gene[data-astro-cid-2nuxbb3n]{display:flex;align-items:baseline;gap:.5rem}.bio-gene[data-astro-cid-2nuxbb3n] .gene-name[data-astro-cid-2nuxbb3n]{font-size:1rem;font-weight:700;font-style:italic;color:#1e293b}.bio-z[data-astro-cid-2nuxbb3n]{font-size:.72rem;color:#94a3b8;font-variant-numeric:tabular-nums;white-space:nowrap}.bio-note[data-astro-cid-2nuxbb3n]{margin:0;font-size:.85rem;color:#475569;line-height:1.45}.bio-link[data-astro-cid-2nuxbb3n]{white-space:nowrap;color:#2c6cb0;text-decoration:none;font-weight:500}.bio-link[data-astro-cid-2nuxbb3n]:hover{text-decoration:underline}.ruled-out[data-astro-cid-2nuxbb3n]{margin-top:2.5rem}.ro-chips[data-astro-cid-2nuxbb3n]{display:flex;flex-wrap:wrap;gap:.5rem;margin-top:.5rem}.ro-chip[data-astro-cid-2nuxbb3n]{display:inline-flex;align-items:baseline;gap:.4rem;padding:.3rem .7rem;background:#f8fafc;border:1px dashed #cbd5e1;border-radius:6px;font-size:.82rem;color:#64748b}.ro-chip[data-astro-cid-2nuxbb3n] .gene-name[data-astro-cid-2nuxbb3n]{font-weight:700;font-style:italic;color:#475569}.ro-z[data-astro-cid-2nuxbb3n]{font-size:.7rem;color:#94a3b8;font-variant-numeric:tabular-nums}.ro-label[data-astro-cid-2nuxbb3n]{font-size:.75rem;color:#94a3b8}.source-note[data-astro-cid-2nuxbb3n]{margin-top:2.5rem;font-size:.85rem;color:#64748b;line-height:1.55}.source-note[data-astro-cid-2nuxbb3n] a[data-astro-cid-2nuxbb3n]{color:var(--primary-color, #2563eb)}@media(max-width:640px){.bio-item[data-astro-cid-2nuxbb3n]{grid-template-columns:1fr}}