[ { "gene": "GPX6", "ensembl": "ENSG00000198704", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "RGPD5", "ensembl": "ENSG00000015568", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "IFNL2", "ensembl": "ENSG00000183709", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 3, "top": [ { "nct": "NCT05797597", "title": "Long-term Aspirin Therapy as a Predictor of Decreased Susceptibility to SARS-CoV-2 Infection in Aspirin-Exacerbated Respiratory Disease", "status": "UNKNOWN", "phases": [ "PHASE3" ] }, { "nct": "NCT03979508", "title": "Abemaciclib in Treating Patients With Surgically Resectable, Chemotherapy Resistant, Triple Negative Breast Cancer", "status": "TERMINATED", "phases": [ "PHASE2" ] }, { "nct": "NCT07622914", "title": "The Role of Dietary Fiber in Mitigating Sarcopenia Risk in Head and Neck Cancer", "status": "RECRUITING", "phases": [] } ] }, "auto_flag": "none" }, { "gene": "TRIM43", "ensembl": "ENSG00000144015", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "TRIM43B", "ensembl": "ENSG00000144010", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "INSL4", "ensembl": "ENSG00000120211", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 1, "top": [ { "nct": "NCT06808165", "title": "Relaxin and Placental Volume in 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"UNKNOWN", "phases": [ "PHASE2" ] }, { "nct": "NCT02498808", "title": "Interferon-lambda: Novel Biologics for Controlling Neutrophil-mediated Pathology in Rheumatic Diseases?", "status": "UNKNOWN", "phases": [] }, { "nct": "NCT00565539", "title": "Study of PEG-rIL-29 (or PEG-IFN Lambda) in Subjects With Chronic Hepatitis C Virus Infection", "status": "COMPLETED", "phases": [ "PHASE1" ] } ] }, "auto_flag": "review" }, { "gene": "PIWIL3", "ensembl": "ENSG00000184571", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "H2BC12L", "ensembl": "ENSG00000234289", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "SCN10A", "ensembl": "ENSG00000185313", "errors": [], "open_targets": { "count": 76, "rows": [ { "stage": "APPROVAL", "drug": "TETRACAINE", "drugType": "Small molecule", "indications": [ "Pain", "hemorrhoid", "Pruritus", "spinal anesthesia", "pulpal anesthesia", "corneal abrasion", "cataract", "postherpetic neuralgia", "carpal tunnel syndrome", "shoulder impingement syndrome", "local anesthesia", "myopic astigmatism", "myopia", "osteoarthritis", "peripheral neuropathic pain", "toothache", "post-intubation sore throat", "anesthesia", "refractive surgery", "phakic intraocular lens surgery", "phakic intraocular lens implantation", "acute kidney injury", "skin reaction", "need root canal treatment", "discomfort of intravenous insertion", "simple lacerations", "laceration" ] }, { "stage": "APPROVAL", "drug": "DRONEDARONE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "atrial fibrillation" ] }, { "stage": "APPROVAL", "drug": "PROCAINE", "drugType": "Small molecule", "indications": [ "hemorrhoid", "anaesthesia", "osteoarthritis", "radiation-induced oral mucositis", "acute kidney injury", "chronic non-cancer pain" ] }, { "stage": "APPROVAL", "drug": "BENOXINATE", "drugType": "Small molecule", "indications": [ "Pruritus", "anaesthesia", "myopia" ] }, { "stage": "APPROVAL", "drug": "ROPIVACAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "fetal growth restriction", "preeclampsia", "unilateral lower limb surgery", "phantom limb pain", "Pain", "postoperative pain", "cancer recurrence", "colorectal cancer", "post-operative pain", "post operative nausea and vomiting", "catheter-related bladder discomfort", "myofascial syndrome", "chronic pelvic pain", "knee arthroscopy", "ovarian cancer", "labour pain", "diaphragmatic dysfunction", "pulmonary complications", "distal upper limb surgery", "supraclavicular brachial plexus block", "Peripheral arterial stenosis", "unplanned caesarean section", "post-surgical pain", "perineal pain", "post-episiotomy perineal pain", "upper limb surgery", "post-sternotomy pain", "ovarian carcinoma", "malignant epithelial tumor of ovary", "hemi-diaphragmatic paresis", "rebound pain", "Low back pain", "postoperative urinary retention", "labor pain", "postoperative recovery", "omalagia", "cesarean section", "Anxiety", "postpartum pelvic floor disorder", "postpartum depression", "surgical operations", "achilles tendinopathy", "rotator cuff syndrome", "shoulder arthroplasty", "anesthesia", "acute postoperative pain", "local anesthetic systemic toxicity", "neurologic toxicity", "posterior eye surgery", "shoulder surgery", "malignant pancreatic neoplasm", "kidney stone pain", "posttraumatic stress disorder", "Headache", "breast augmentation", "abdominoplasty", "laparoscopy-assisted open ventral hernia repair", "bunionectomy", "total knee arthroplasty", "chronic polypous rhinosinusitis", "chronic rhinosinusitis", "Inguinal hernia", "postoperative fatigue", "dental anesthesia", "upper extremity vascular hemodynamic impairment", "vasodilatation", "squamous hyperplasia", "lichen sclerosus et atrophicus", "rib fracture", "lacertus fibrosus syndrome", "ulnar nerve compression", "stub finger", "Dupuytren Contracture", "carpal tunnel syndrome", "Chronic pain", "postoperative delirium", "postoperative cognitive dysfunction", "post-traumatic stress disorder", "lower limb joint damage", "lower back surgery", "third molar extraction surgery", "upper extremity orthopedic surgery", "subgluteal sciatic nerve block", "pain after surgery", "residual pain", "stump pain", "posterior vaginal wall prolapse", "hyperalgesia", "regional anesthesia", "emergency caesarean section", "post-cesarean pain", "mobilization delay after total hip arthroplasty", "opioid consumption", "supracondylar elbow fracture", "infraclavicular brachial plexus block", "hemodynamic changes", "osteoarthritis", "neurologic injury", "distal sciatic nerve block", "nerve damage", "post-thoracotomy pain", "carotid endarterectomy", "intraoperative pain", "residual limb pain", "upper extremity surgery", "operative anesthesia", "Knee pain", "outpatient laparoscopy", "laparoscopic gynecological surgery", "adverse events", "phrenic nerve blockade", "ipsilateral hemidiaphragm paresis", "pulmonary dysfunction", "spinal anesthesia", "brachial plexus block", "carotid artery surgery", "upper limb orthopedic surgery", "proximal femur fracture", "hip fracture", "delirium", "acute pain", "cholelithiasis", "Cholecystitis", "biliary dyskinesia", "upper limb surgical anesthesia", "hip surgery", "cesarean delivery", "post-operative major complications", "Hallux valgus", "pain after total abdominal hysterectomy", "arteriovenous fistula", "acute kidney injury", "ventral hernia", "medial leg surgery", "medial foot surgery", "medial ankle surgery", "vascular access surgery of the upper arm", "post-surgery pain", "surgical delivery", "postoperative shoulder pain", "cataract", "post-video-assisted thoracotomy pain", "femur fracture", "aneurysm", "breast cancer", "hemidiaphragmatic paralysis", "hemidiaphragmatic paresis", "postoperative abdominal pain", "cerebral palsy", "post-laparoscopic cholecystectomy pain", "motor block", "nerve block", "formarm or hand surgery", "ocular surgery", "open radical cystectomy", "radical retropubic prostatectomy", "pelvic urologic surgery", "lack of muscle relaxation", "hypotensive disorder", "Horner syndrome", "postoperative sore throat", "abdominal bone flap cranioplasty", "epidermolysis bullosa", "pain with movement", "pain at rest", "chronic post-surgical pain", "proximal femoral fractures", "post-craniotomy pain", "spinal anaesthesia", "Increased intracranial pressure", "pain following breast surgery", "postherniorrhaphy pain", "neuropathic pain", "catheter related bladder discomfort syndrome", "femoral shaft fractures", "multiple precancerous colon polyps", "inflammatory bowel disease", "malignant colon neoplasm", "acute gastrointestinal injury", "quadriceps muscle weakness", "positional pain", "pertrochanteric femoral fracture", "functional recovery", "osteoarthritis, knee", "gastric cancer", "chronic post-thoracotomy pain", "perioperative neurocognitive dysfunction", "chronic low-back pain", "pain following shoulder arthroplasty", "spastic paresis", "abdominal neoplasia", "lumbar spine surgery", "neonatal depression", "shoulder pathology", "knee arthroplasty", "Dilatation of the cerebral artery", "obstetric perineal lacerations", "meniscal tear", "heart failure with reduced ejection fraction", "visceral pain", "osteoarthritis, hip", "persistent pain post mastectomy", "symptomatic hip dysplasia", "congenital pulmonary cystic disease", "open lumbar infrarenal aortic aneurysm repair", "chronic non-cancer pain", "shoulder ligament rupture", "lower limb bypass surgery", "sacral plexus anesthesia", "lower limb injury", "pain associated with herpes zoster", "postherpetic neuralgia", "postural tachycardia syndrome", "arteriovenous fistula surgery", "prolonged disorders of consciousness", "postoperative nausea" ] }, { "stage": "APPROVAL", "drug": "CENOBAMATE", "drugType": "Small molecule", "indications": [ "Seizure", "Focal impaired awareness seizure", "epilepsy", "partial-onset epilepsy", "partial onset seizures", "primary generalized tonic-clonic seizures", "focal to bilateral tonic-clonic seizures", "focal aware motor seizures", "partial-onset seizures", "generalized tonic-clonic seizures", "photosensitive epilepsy", "Focal-onset seizure", "acute frequent seizures", "status epilepticus", "focal onset epilepsy", "focal epilepsy" ] }, { "stage": "APPROVAL", "drug": "CHLOROPROCAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "distal upper limb surgery", "unplanned caesarean section", "postoperative pain", "postoperative nausea", "cataract", "ocular surface anesthesia", "hemorrhoidectomy", "knee surgery", "Inguinal hernia", "flatfoot", "post-partum tubal ligation", "labor pain", "cesarean delivery", "surgical pain", "spinal anesthesia", "epidural anesthesia", "ambulatory minor foot surgery", "acute kidney injury", "Umbilical hernia", "knee arthroscopy", "cervical cerclage", "inguinal herniorrhaphy", "ambulatory knee arthroscopy", "motor block", "knee arthroplasty", "hip arthroplasty", "cesarean section", "manipulation under anesthesia" ] }, { "stage": "APPROVAL", "drug": "MEPHENYTOIN", "drugType": "Small molecule", "indications": [ "epilepsy" ] }, { "stage": "APPROVAL", "drug": "ETHOTOIN", "drugType": "Small molecule", "indications": [ "Seizure", "Focal impaired awareness seizure", "epilepsy" ] }, { "stage": "APPROVAL", "drug": "ARTICAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "nerve", "Pain", "irreversible pulpitis", "pulpal anesthesia", "skin anesthesia", "acne scars", "traumatic scars", "local anesthesia", "maxillary tooth extraction", "tooth extraction", "dental phobia" ] }, { "stage": "APPROVAL", "drug": "FOSPHENYTOIN", "drugType": "Small molecule", "indications": [ "epilepsy", "IgA glomerulonephritis", "status epilepticus", "non-convulsive status epilepticus", "nonconvulsive seizures", "Pain", "herpes zoster", "trigeminal neuralgia", "acute brain injury" ] }, { "stage": "APPROVAL", "drug": "TOCAINIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "INDECAINIDE", "drugType": "Small molecule", "indications": [ "dysrhythmias" ] }, { "stage": "APPROVAL", "drug": "PROPOXYCAINE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "APPROVAL", "drug": "PROCAINAMIDE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Ventricular arrhythmia", "cardiac arrhythmia" ] }, { "stage": "APPROVAL", "drug": "PROPAFENONE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "tachyarrhythmias", "ventricular fibrillation", "atrial fibrillation", "outflow tract ventricular arrhythmias", "supraventricular arrhythmias", "ventricular ectopy" ] }, { "stage": "APPROVAL", "drug": "DYCLONINE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "APPROVAL", "drug": "PRILOCAINE", "drugType": "Small molecule", "indications": [ "Pain", "anaesthesia", "physiological sexual disorder", "sensory function impairment", "spinal anesthesia", "cesarean section", "circumcision", "hemodynamics", "Hydrocele testis", "spermatocele", "arthroscopy on the knee", "premature ejaculation", "postherpetic neuralgia", "scheduled cesarean delivery", "motor block", "amnestic mild cognitive impairment", "venepuncture pain", "knee surgery", "below knee orthopedic surgery", "methemoglobinemia", "Cyanosis", "distal sciatic nerve block", "nerve damage", "anal surgery", "regional anesthesia", "carotid artery surgery", "knee arthroscopy", "acute kidney injury", "Inguinal hernia", "Umbilical hernia", "radial artery spasm", "forehead rhytides", "maxillary teeth extraction", "stress", "abnormal uterine bleeding", "postoperative pain", "upper extremity surgery", "cystoscopy procedures", "cardiac dysfunction", "peripheral vascular disease", "subacromial impingement syndrome", "rotator cuff lesion", "Shoulder pain", "hypotensive disorder", "fear", "arteriovenous fistula", "perianal surgery", "osteoarthritis, knee", "total knee replacement", "postoperative shivering" ] }, { "stage": "APPROVAL", "drug": "COCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "cocaine dependence", "cocaine use disorder" ] }, { "stage": "APPROVAL", "drug": "QUINIDINE SULFATE", "drugType": "Small molecule", "indications": [ "Alzheimer disease", "probable Alzheimer's disease", "Agitation", "dementia", "dementia of the Alzheimer's type", "schizophrenia", "neurobehavioral disorder", "Parkinson disease", "autism spectrum disorder", "major depressive disorder", "disinhibition syndrome", "amyotrophic lateral sclerosis", "Pain", "neurobehavioral manifestations", "pseudobulbar affect" ] }, { "stage": "APPROVAL", "drug": "ROPIVACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Pain", "glenohumeral arthritis", "brachial plexus block", "intrapartum pain", "labour pain", "acute pain" ] }, { "stage": "APPROVAL", "drug": "DISOPYRAMIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia", "atrial fibrillation", "Urinary incontinence" ] }, { "stage": "APPROVAL", "drug": "DISOPYRAMIDE PHOSPHATE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "OXCARBAZEPINE", "drugType": "Small molecule", "indications": [ "epilepsy", "Seizure", "focal epilepsy", "Focal-onset seizure", "aggressive behavior", "Agitation", "partial onset seizures", "partial onset epilepsy", "localization related epilepsy", "neuropathic pain", "schizophreniform disorder", "schizophrenia", "multiple sclerosis", "cancer pain", "autism", "peripheral neuropathic pain", "compulsive sexual behavior", "bipolar disorder", "trigeminal neuralgia" ] }, { "stage": "APPROVAL", "drug": "QUINIDINE GLUCONATE", "drugType": "Small molecule", "indications": [ "Ventricular arrhythmia", "malaria" ] }, { "stage": "APPROVAL", "drug": "ESLICARBAZEPINE", "drugType": "Small molecule", "indications": [ "epilepsy" ] }, { "stage": "APPROVAL", "drug": "RUFINAMIDE", "drugType": "Small molecule", "indications": [ "tonic and atonic seizures", "Seizure", "Lennox-Gastaut syndrome", "epilepsy", "pediatric lennox-gastaut syndrome", "Focal-onset seizure", "generalized anxiety disorder", "neuropathic pain", "Chronic pain" ] }, { "stage": "APPROVAL", "drug": "DRONEDARONE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "angina pectoris", "atrial fibrillation", "atrial flutter", "left ventricular dysfunction", "congestive heart failure", "Paroxysmal atrial fibrillation", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "RILUZOLE", "drugType": "Small molecule", "indications": [ "amyotrophic lateral sclerosis", "progressive supranuclear palsy", "multiple system atrophy", "Huntington disease", "Myelopathy", "spinocerebellar ataxia type 2", "cerebellar ataxia", "spinal muscular atrophy", "spinal cord injury", "social phobia", "spinocerebellar ataxia 7", "Parkinson disease", "major depressive disorder", "depressive disorder", "bipolar disorder", "cerebellar syndrome", "obsessive-compulsive disorder", "multiple sclerosis", "Anxiety", "melanoma", "Irritability", "Hyperactivity", "autism spectrum disorder", "Alzheimer disease", "frontotemporal dementia", "Spasticity", "atrial fibrillation", "Tachycardia", "cancer-related cognitive impairment", "post-traumatic stress disorder", "breast cancer", "brain metastasis", "solid tumors", "colorectal cancer", "schizophrenia", "spastic hyper-reflexia" ] }, { "stage": "APPROVAL", "drug": "LAMOTRIGINE", "drugType": "Small molecule", "indications": [ "epilepsy", "bipolar disorder", "major depressive disorder", "Seizure", "bipolar I disorder", "Bilateral tonic-clonic seizure", "Lennox-Gastaut syndrome", "focal epilepsy", "partial onset seizures", "mania", "hypomania", "depressive disorder", "peripheral neuropathy", "schizophrenia", "bipolar II disorder", "childhood absence epilepsy", "primary generalized tonic-clonic seizures", "Focal-onset seizure", "eating disorder", "obesity disorder", "simple partial seizures", "partial seizures with secondary generalization", "Focal impaired awareness seizure", "alcohol dependence", "post-traumatic stress disorder", "mood disorder", "Typical absence seizure", "localization related epilepsy", "Myotonia", "psychologic side-effect", "non-dystrophic myotonia", "post-herpetic neuralgia", "trigeminal neuralgia", "neurofibromatosis type 1", "ketamine dependence", "opiate withdrawal", "unipolar mood disorders", "cocaine dependence", "bipolar mood disorder", "mixed mania", "disability", "multiple sclerosis", "pathologic skin picking", "neurotic excoriation", "Meniere disease", "Cognitive impairment", "alcohol use", "Vertigo", "Generalized non-motor (absence) seizure", "bipolar mood disorders", "memory loss", "mood changes", "alcohol withdrawal", "neuropathic facial pain", "premenstrual dysphoric disorder", "unipolar major depressive disorder", "Generalized-onset seizure", "neuralgia", "migraine disorder", "bipolar II depression", "acute postoperative pain", "post-mastectomy pain syndrome", "mood instability" ] }, { "stage": "APPROVAL", "drug": "COCAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "cocaine craving", "cocaine dependence", "cocaine abuse", "cocaine use disorder", "cardiovascular effects of cocaine" ] }, { "stage": "APPROVAL", "drug": "PHENYTOIN SODIUM", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "cancer" ] }, { "stage": "APPROVAL", "drug": "ZONISAMIDE", "drugType": "Small molecule", "indications": [ "epilepsy", "Seizure", "Parkinsonism", "Parkinson disease", "focal epilepsy", "binge eating disorder", "Obesity", "simple partial seizures", "partial seizures with secondary generalization", "Focal impaired awareness seizure", "Focal-onset seizure", "partial onset seizures", "primary generalised tonic-clonic seizures", "early-infantile DEE", "myoclonus-dystonia syndrome", "alcohol dependence", "alcohol abuse", "cigarette smoking", "nicotine dependence", "migraine disorder", "Tremor", "essential tremor", "obesity disorder", "heavy drinking", "bipolar disorder", "obstructive sleep apnea syndrome", "post-traumatic stress disorder", "hearing loss disorder", "cocaine dependence", "focal epileptic seizures", "partial onset epileptic crisis", "levodopa-induced dyskinesia", "motor fluctuations", "nonmotor symptoms", "Cognitive impairment", "partial-onset seizures" ] }, { "stage": "APPROVAL", "drug": "PROPAFENONE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "atrial fibrillation", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "PHENAZOPYRIDINE", "drugType": "Small molecule", "indications": [ "Pain", "voiding dysfunction", "postoperative urinary retention", "middle east respiratory syndrome (mers)" ] }, { "stage": "APPROVAL", "drug": "QUINIDINE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "ventricular fibrillation", "Sudden death", "ventricular tachycardia", "atrial fibrillation", "pseudobulbar affect", "amyotrophic lateral sclerosis", "peripheral neuropathic pain", "diabetic peripheral neuropathy", "Irritability", "diabetic neuropathy", "neuropathic pain", "multiple sclerosis", "Agitation", "Alzheimer disease", "levodopa-induced dyskinesia", "Parkinson disease", "major depressive disorder", "paroxysmal familial ventricular fibrillation", "multifocal ectopic Purkinje-related premature contractions", "Andersen-Tawil syndrome", "traumatic brain injury" ] }, { "stage": "APPROVAL", "drug": "PHENYTOIN", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "hypomanic symptoms", "memory impairment", "febrile status epilepticus", "Convulsive status epilepticus", "malignant pancreatic neoplasm", "invasive ductal breast carcinoma", "pancreatic ductal adenocarcinoma", "exocrine pancreatic carcinoma", "neuropathic pain", "polyneuropathy", "gingival recession", "prostate cancer", "human immunodeficiency virus infection", "optic neuritis", "nodding syndrome", "surgical wounds", "Ewing sarcoma", "sarcoma", "non-malignant disorder", "malignant disorder", "cocaine use disorder", "injury", "chronic anal fissure", "Anal fissure", "bronchial asthma", "impulsive aggression", "post-traumatic stress disorder", "subarachnoid hemorrhage", "Anal fistula", "osteonecrosis of the mandible", "osteonecrosis of the jaw", "status epilepticus", "atrophic acne scars" ] }, { "stage": "APPROVAL", "drug": "MORICIZINE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Arrhythmia", "atrial fibrillation", "complex ventricular arrhythmia", "heart arrhythmia" ] }, { "stage": "APPROVAL", "drug": "CARBAMAZEPINE", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "trigeminal neuralgia", "glossopharyngeal nerve disorder", "focal epilepsy", "bipolar I disorder", "bipolar disorder", "type 1 diabetes mellitus", "gastric adenocarcinoma", "partial onset seizures", "generalized tonic-clonic seizures", "partial-onset seizures", "cocaine dependence", "cocaine craving", "infantile spasms", "human immunodeficiency virus drug resistance", "human immunodeficiency virus infection", "liver disorder", "facial pain", "schizophrenia", "bronchial asthma", "generalised tonic-clonic seizures", "Focal-onset seizure", "premenstrual dysphoric disorder", "Irritability", "aggressive behavior", "carpal tunnel syndrome", "inherited erythromelalgia", "alcohol withdrawal", "drug-resistant epilepsy", "substance use disorder" ] }, { "stage": "APPROVAL", "drug": "MEPIVACAINE", "drugType": "Small molecule", "indications": [ "pain agnosia", "severe pain", "Pain", "motor deficit", "visual scotoma", "Cerebral visual impairment", "Aphasia", "compartment syndrome", "knee arthroscopy surgery", "distal upper extremity surgery", "anesthesia", "shoulder arthroscopy", "irreversible pulpitis", "knee arthroscopy", "ambulatory minor foot surgery", "gingival recession", "Miller class I gingival recession", "third molar extraction", "acute kidney injury", "upper limb pain", "formarm or hand surgery", "ischemic hypertension", "pain during maxillary teeth extraction", "tooth decay", "hip arthroplasty", "postoperative pain", "sensory blockade", "total hip arthroplasty", "total knee arthroplasty", "carpal tunnel syndrome" ] }, { "stage": "APPROVAL", "drug": "PRIMIDONE", "drugType": "Small molecule", "indications": [ "epilepsy", "clopidogrel resistance", "essential tremor" ] }, { "stage": "APPROVAL", "drug": "LIDOCAINE", "drugType": "Small molecule", "indications": [ "premature ejaculation", "Pruritus", "burn", "sunburn", "Back pain", "osteoarthritis", "Pain", "Ventricular arrhythmia", "digestive system disease", "Myalgia", "Muscle spasm", "disease of the tendon", "arthritic joint disease", "frozen shoulder", "urethritis", "hemorrhoid", "sprain", "neuralgia", "cardiac arrhythmia", "anaesthesia", "inflammation", "physiological sexual disorder", "infection", "neuropathic pain", "visceral pain", "postoperative recovery", "colorectal neoplasm", "spinal anesthesia", "carpal tunnel syndrome", "diabetic polyneuropathy", "postherpetic neuralgia", "overactive bladder", "procedural pain", "ileus", "post-tonsillectomy pain", "poor oral intake", "pharyngitis", "radiation skin reaction", "preeclampsia", "endoscopic sinus surgery", "sensory function impairment", "bursitis of the shoulder", "tendinitis", "ankle sprain", "forearm surgery", "arm surgery", "Laryngospasm", "fibromyalgia", "ventricular fibrillation", "ventricular tachycardia", "post-herniorrhaphy pain", "subacromial tendonitis", "supraspinatous tendonitis", "subdeltoid bursitis", "bursitis", "pain with sexual intercourse", "Dyspareunia", "Modic I discopathy", "Low back pain", "inevitable abortion", "missed abortion", "pregnancy", "incomplete abortion", "intubation", "transitory neurologic syndrome", "greater trochanteric pain syndrome", "breast cancer", "submental fullness", "cataract", "postoperative sore throat", "Cough", "Hoarse voice", "cancer pain", "peripheral neuropathic pain", "Chronic pain", "type 2 diabetes mellitus", "abortion", "feticide", "fetal asystole", "hand surgery", "delayed onset muscle soreness", "myofascial pelvic pain", "postoperative pain", "pulpitis", "large-vessel occlusion", "ischemic stroke", "chronic post-surgical pain", "intrauterine device insertion pain", "circumcision", "Headache", "Neck pain", "post-dural puncture headache", "Obesity", "migraine disorder", "acute musculoskeletal pain", "Sepsis", "septic shock", "glenohumeral arthritis", "cough reflex", "post-operative pain", "pelviabdominal cancers", "stenosing tenosynovitis", "de Quervain disease", "Digital flexor tenosynovitis", "labor pain", "colorectal cancer", "non-small cell lung carcinoma", "postthoracotomy pain", "dental restorative cases", "Anxiety", "hip fracture", "total hip arthroplasty", "acute respiratory distress syndrome", "pneumonia", "myofascial pain syndrome", "acute pain", "cardiac surgery", "acute respiratory distress", "postoperative ileus", "postoperative cognitive dysfunction", "postoperative delirium", "disability", "osteoarthritis, knee", "post-surgical pain", "cancer", "Ehlers-Danlos syndrome, hypermobility type", "post-operative oral pain", "volume deficit of the midface", "lumbar disc herniation", "mixed vaginal infections", "vulvovaginal candidiasis", "vaginitis", "bacterial vaginosis", "Hydrocele testis", "spermatocele", "postoperative complications", "central post-stroke pain", "difficult airway", "pudendal neuralgia", "local anesthesia", "postoperative pulmonary complications", "distal radius fracture", "postoperative cough", "chronic nasal congestion", "Dyspnea", "Respiratory distress", "obstructive sleep apnea syndrome", "sleep disorder", "scleroderma", "diabetic neuropathy", "topical anesthesia", "radial artery spasm", "anal hypertonia", "postoperative chronic pain", "Knee pain", "hematopoietic and lymphoid cell neoplasm", "irreversible pulpitis", "lateral epicondylitis", "complex regional pain syndrome", "dermatologic surgical procedure", "snakebite envenomation", "connective tissue neoplasm", "bone neoplasm", "Anal fissure", "cesarean section", "nasal surgery", "recovery of postoperative gastrointestinal function", "myofascial pain", "Dysmenorrhea", "painful diabetic neuropathy", "HIV-associated neuropathy", "cutaneous heat hyperalgesia", "visceral hyperalgesia", "clinical pain", "irritable bowel syndrome", "infertility disorder", "vulvar vestibulitis", "hemiplegia", "Shoulder pain", "chronic axial low back pain", "Stress urinary incontinence", "hand impairment", "Hemiparesis", "generalized vulvodynia", "interstitial cystitis", "shoulder impingement syndrome", "opioid consumption", "bowel dysfunction", "breast cancer recurrence", "post operative nausea and vomiting", "vasoocclusive sickle cell pain", "endometriosis", "tonsillectomy", "infective endocarditis", "heart valve disorder", "diabetic peripheral neuropathy", "discomfort during upper gastrointestinal endoscopy", "cocaine dependence", "adductor canal block", "complex regional pain syndrome type 2", "phantom limb pain", "scar hyperalgesia", "lumbar plexus block", "stress response of intubation", "allodynia", "anesthesia of the tympanic membrane", "renal colic", "upper extremity trauma", "Infertility", "aorto-iliac aneurysm", "postdural puncture headache", "mastodynia", "vestibulodynia", "leg ulcer", "painful trigeminal neuropathy", "trigeminal neuralgia", "blood loss", "malignant pancreatic neoplasm", "short surgery", "sickle cell crisis", "rib fracture", "myogenous face pain", "jaw muscle pain", "posttraumatic stress disorder", "anxiety symptoms", "tooth extraction", "pain following wisdom molar extractions", "chronic scrotal content pain", "malignant wounds", "peripheral neuropathy", "chronic pancreatitis", "post-extubation cough", "wound dehiscence", "surgical site swelling", "surgical site ecchymosis", "hematoma", "myofascial pain dysfunction syndrome", "mandibular permanent molars", "malignant colon neoplasm", "tourniquet-induced hypertension", "orofacial pain", "solid tumor", "delayed bowel function", "chronic migraine", "craniofacial neuralgia", "heart failure", "malignant pleural effusion", "perioperative pain", "brain neoplasm", "molar incisor hypomineralisation", "amnestic mild cognitive impairment", "molar-incisor hypomineralization", "venepuncture pain", "postoperative recovery quality", "hyperalgesia", "radial artery vasospasm", "radial artery vasodilation", "anesthesia", "provoked localized vulvodynia", "pancreatic cystic neoplasms", "pain agnosia", "lumbar radiculopathy", "herpes zoster", "pulmonary hypertension", "Morton Neuroma", "leg dominant pain", "Tinnitus", "migraine-like headache", "mandibular tooth extraction", "greater occipital neuralgia", "liver cancer", "supratentorial tumors", "lumbar disc related radicular pain", "lacertus fibrosus syndrome", "ulnar nerve compression", "stub finger", "Dupuytren Contracture", "diabetic foot", "spinal cord injury", "Plantar Fasciitis", "cortisol level post-intubation", "hemodynamic changes", "nerve damage", "pelvi-abdominal cancer", "procedure related pain", "prostate cancer", "oropharynx squamous cell carcinoma", "Inguinal hernia", "radiculitis", "temporomandibular disorders", "cesarean delivery", "postoperative nasal bleeding", "epistaxis", "cold pain", "headache disorder", "musculoskeletal pain", "chronic cancer-related pain", "vulvodynia", "perineal laceration", "perineal pain", "recovery following total abdominal hysterectomy", "vasovagal reaction", "skin cancer", "restless legs syndrome", "pain after surgery", "acute functional recovery after abdominal hysterectomy", "residual pain", "uterine curettage", "post-intubation sore throat", "postoperative swelling", "postoperative inflammation", "trochanteric bursitis", "idiopathic distal sensory neuropathy", "post-mastectomy pain syndrome", "pelvic floor tension myalgia", "masticatory myofascial pain", "Mydriasis", "Hypertension", "sensoric blockade", "motoric blockade", "refractive surgery", "methemoglobinemia", "Cyanosis", "perioperative coughing", "provoked vestibulodynia", "digital nerve block", "diabetic macular edema", "wet macular degeneration", "retinal vein occlusion", "post-herpetic neuralgia", "occipital neuralgia", "spinal block", "myocardial injury", "Arrhythmia", "loss of fatty tissue", "discomfort", "rocuronium injection pain", "Isolated systolic hypertension", "transurethral resection of prostate", "endophthalmitis", "post surgical pain", "sensory disturbances", "abnormal uterine bleeding", "cholangiocarcinoma", "intrahepatic cholangiocarcinoma", "nasal septoplasty surgery", "endometriosis pain", "fluctuance", "cellulitis", "upper extremity surgical anesthesia", "sensory and motor nerve block", "nasolabial folds", "skin erythema", "jellyfish sting", "outpatient laparoscopy", "laparoscopic gynecological surgery", "eyelid surgery", "burn injury", "patients undergoing IVRA for short operations on arm and forearm", "discomfort associated with placing a catheter in a vein", "peripheral nerve block", "hip joint pain", "phakic intraocular lens implantation", "break-through pain", "skin anesthesia", "anesthesia induction", "post-caesarean section incisional pain", "epidural anesthesia", "painful neuroma", "intolerance to endoscopy", "pre-operative sedation", "postoperative analgesia", "axillary brachial plexus block", "rhytidoplasty", "facelift surgery", "sacroiliac joint dysfunction", "plantar fasciopathy", "spastic flexion pattern of the elbow", "laryngo tracheal reflexes", "neuromuscular blockade", "second degree burn", "upper extremity surgery", "surgical anesthesia", "Pilonidal sinus", "acne scars", "traumatic scars", "cervical incompetence", "post-operative major complications", "achilles tendinopathy", "biceps tendinitis", "superficial venous insufficiency", "acute ischemic stroke", "heart failure with reduced ejection fraction", "discomfort of dental injections", "diabetes mellitus", "rotator cuff syndrome", "arteriovenous fistula", "acute kidney injury", "oesophagogastroduodenoscopy", "maxillary field block anesthesia", "abdominal wall pain", "Arthritis", "voiding efficiency impairment", "Urinary retention", "mixed urinary incontinence", "chronic lumbosacral radicular pain", "benign anorectal surgery", "pharyngolaryngeal discomfort", "propofol injection pain", "abdominal cancer pain", "rotator cuff impingement syndrome", "flexor tendon injuries", "hand and forearm pain", "hand injury", "post-laparoscopy shoulder pain", "dental procedures", "cervical radicular pain", "ocular surgery", "awake nasal fiberoptic intubation", "trauma of the upper limb", "injury", "muscle tremor", "shoulder arthroplasty", "severe airways obstruction", "cutaneous inflammation", "brachial plexus block", "major abdominal surgeries", "hemodynamic response to laryngoscopy and intubation", "popliteal block", "anterior shoulder dislocation", "voiding efficiency", "bladder emptying", "brachial plexus blockade", "vulvar biopsy pain", "postthoracotomy pain syndrome", "chronic postoperative pain", "mid-face volume deficit", "nociceptive pain", "forehead rhytides", "post-cesarean pain", "Dilatation of the cerebral artery", "extubation response", "transient neurological syndrome", "pain following circumcision", "quervain syndrome", "acute respiratory failure", "onset time of local anesthesia", "bronchial disorder", "shoulder tip pain", "burn scar", "simple lacerations", "gag reflex", "infraclavicular brachial plexus block", "achilles enthesopathy", "diabetic peripheral neuropathic pain", "post mastectomy pain syndrome", "stress", "quality of recovery", "iatrogenic pain", "foot surgery", "ankle surgery", "acute abdominal pain", "post dural puncture headache", "recovery quality after gynecological laparoscopy", "bucking", "dental anesthesia", "toothache", "laceration", "diagnostic curettage", "hysteroscopy", "neurogenic cough", "stress response to direct laryngoscopy", "Periodontal Pocket", "gynaecology surgery", "dental extraction", "upper limb surgical anaesthesia", "intractable plantar keratoma", "non-histaminergic itch", "gastric cancer", "pes anserine bursitis", "lip volume deficiency", "lumbar spine surgery", "Vomiting", "Nausea", "residual limb pain", "arteriovenous fistula failure", "chondromalacia patellae", "behavior", "acromioclavicular joint dysfunction", "bone marrow biopsy", "palatal anesthesia", "thyroidectomy", "pruritus ani", "pancreatic malignancy", "Hyperhidrosis", "female reproductive organ cancer", "piriformis syndrome", "muscle function impairment", "tussis", "left ventricular systolic dysfunction", "coronary artery disorder", "chronic pelvic pain", "postoperative delay in resumption of normal bowel function", "cervical cancer", "hemiplegic shoulder pain", "upper airway discomfort", "traumatic cervical injury", "postoperative bleeding", "mesothelioma", "bronchogenic carcinoma", "supratentorial craniotomy", "hypertrophy of labia minor", "incompetent long saphenous vein", "chronic venous disease", "varicose ulcer", "Varicose veins", "dental injection pain", "wisdom tooth extraction", "odontectomy", "post-tonsillectomy hemorrhage", "surgery of forearm, wrist, and hand", "post-thoracotomy pain syndrome", "wound infection", "hemodynamic responses to pneumoperitoneum", "abdominal eventration", "port access pain", "surgical stress response", "neuropathic foot pain", "coxarthrosis", "infectious peritonitis", "postoperative neurocognitive dysfunction", "gastroscopy", "extraction of mandibular molar", "traumatic oral ulcer", "non-sedated esophagogastroduodenoscopy", "subacromial bursitis", "Dysphagia", "cerebral palsy", "postoperative pneumonia", "atelectasis", "pharyngeal dysphagia", "gastroesophageal reflux disease", "fear", "zoster-associated pain", "stress response to laryngoscopy", "stress response to endotracheal intubation", "persistent pain post mastectomy", "hemodynamic instability", "postoperative vomiting", "postoperative nausea", "devitalized mandibular molar tooth", "perioperative neurocognitive disorders", "hemodynamic response", "nociception level index", "persistent idiopathic facial pain", "upper gastrointestinal disorders", "chronic upper back pain", "chronic mid back pain", "first trimester incomplete miscarriage", "incomplete miscarriage", "endometrial biopsy pain", "post-induction hypotension", "early intraoperative hypotension", "postpartum perineal pain", "stage 5 chronic kidney disease", "chronic idiopathic ano-perineal pain", "chronic non-cancer pain", "supraspinatus tendon injury", "sacroiliac joint pain", "recovery", "palmar hyperhidrosis", "emergency laparotomy", "endometrial thickening", "pain on injection of rocuronium", "suboptimal recovery", "heightened oral secretions", "gut function", "Insulin resistance", "increased intraocular pressure", "difficult mask ventilation", "postoperative discomfort", "cervicogenic dizziness", "atopic eczema", "discomfort during fiberoptic bronchoscopy", "complications of anesthesia and surgery", "cardiovascular responses to tracheal intubation", "pain on injection of propofol", "infected tooth", "inflamed tooth", "hypotensive disorder", "traumatic oral ulcers", "intubation condition", "hemodynamic responses to laryngoscopy", "Tachycardia", "laparoscopic cholecystectomy", "gynecologic surgery", "hepatic metastases", "hepatocellular carcinoma", "postoperative pain scores", "Hoffa's fat pad impingement", "arteriovenous fistula surgery", "emergence agitation", "hemorrhoidal prolapse", "perioperative nociceptive control", "ambulatory hand surgery", "ambulatory foot surgery", "leg telangiectasias", "Popliteal synovial cyst", "neuroma-related pain", "postoperative emergence agitation", "postoperative trismus", "lumbar spinal surgery", "postoperative cognitive delirium", "pulmonary injury", "chronic neck pain", "orbital akinesia", "stress of endotracheal intubation", "medication overuse headache" ] }, { "stage": "APPROVAL", "drug": "ORPHENADRINE", "drugType": "Small molecule", "indications": [ "Parkinson disease", "muscle cramp", "Low back pain", "osteoarthritis", "Pain", "postoperative ileus", "postoperative pain", "musculoskeletal system disorder", "Neck pain" ] }, { "stage": "APPROVAL", "drug": "ORPHENADRINE CITRATE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "APPROVAL", "drug": "PROPARACAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "corneal abrasion", "myopia", "primary angle closure", "primary angle-closure glaucoma" ] }, { "stage": "APPROVAL", "drug": "FOSPHENYTOIN SODIUM", "drugType": "Small molecule", "indications": [] }, { "stage": "APPROVAL", "drug": "LIDOCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Pain", "Back pain", "prostate carcinoma", "sensory function impairment", "middle ear effusion", "copper intrauterine device insertion", "acute pain", "perineal laceration", "migraine disorder", "Hydrocele testis", "spermatocele", "Cough", "recovery of postoperative gastrointestinal function", "postoperative pain", "postoperative sore throat", "hemiplegia", "Shoulder pain", "interstitial cystitis", "hemorrhoid", "tympanostomy tube placement", "outpatient hysteroscopy", "mandibular permanent molars", "irreversible pulpitis", "subarachnoid hemorrhage", "Headache", "venepuncture pain", "actinic keratosis", "malignant hypertension", "internal hemorrhoids", "cardiac arrest", "exocrine pancreatic carcinoma", "lumbar stenosis", "nervous system disorder", "rotator cuff disease", "ureteral stent symptoms", "break-through pain", "pre-operative sedation", "second degree burn", "impacted lower third molars", "carpal tunnel syndrome", "primary maxillary second molars", "cognitive dysfunction", "vulvar biopsy pain", "wound pain", "limited spine mobility", "axial spondyloarthritis", "cataract", "frozen shoulder", "supratentorial craniotomy", "ear tube placement procedure", "maxillary tooth extraction", "Dysphagia", "Cognitive impairment", "cerebral small vessel disease", "pharyngeal dysphagia", "Stroke", "obstructive sleep apnea syndrome", "insomnia", "autism", "Parkinson disease", "traumatic brain injury", "gastroesophageal reflux disease", "cerebral palsy", "bulbar palsy", "ischemic stroke", "temporomandibular joint dysfunction", "Parkinson's syndrome", "Drooling", "Obesity", "postpartum perineal pain", "post-operative pain", "discomfort during fiberoptic bronchoscopy", "hemodynamic responses to laryngoscopy", "Tachycardia", "Hypertension", "radicular pain", "lumbar disc herniation" ] }, { "stage": "APPROVAL", "drug": "DIBUCAINE", "drugType": "Small molecule", "indications": [ "sunburn", "hemorrhoid", "Pruritus", "anaesthesia" ] }, { "stage": "APPROVAL", "drug": "MEXILETINE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "ventricular tachycardia", "ventricular fibrillation", "Sudden death", "diabetic neuropathy", "non-dystrophic myotonia", "myotonic disorders", "myotonic dystrophy type 1", "myotonic dystrophy type 2", "sodium channel myotonia", "paramyotonia congenita of Von Eulenburg", "Thomsen and Becker disease", "congenital myotonia", "dystonic disorder", "stump pain", "postamputation pain", "phantom pain", "nondystrophic myotonia", "amyotrophic lateral sclerosis", "Muscle stiffness", "Charcot-Marie-Tooth disease", "muscle cramp", "irritable bowel syndrome", "cryptogenic sensory polyneuropathy", "sudden cardiac arrest", "Myotonia" ] }, { "stage": "APPROVAL", "drug": "ARTICAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "spinal anesthesia", "lower limb surgery", "pulpitis", "local anesthesia", "Pain", "ocular anesthesia", "soft tissue local anesthesia effect", "irreversible pulpitis", "pulpal anesthesia", "tooth extraction", "molar incisor hypomineralisation", "molar-incisor hypomineralization", "mandibular tooth extraction", "upper limb procedure", "nerve damage", "mandibular molar extraction", "acute pain", "upper gastrointestinal endoscopy", "extraction of lower third molars", "acute kidney injury", "maxillary teeth extraction", "dental procedures", "lower wisdom teeth extraction", "lower third molar extraction", "pain during maxillary teeth extraction", "tooth decay", "behavior", "wisdom tooth extraction", "odontectomy", "high frenal attachment", "extraction of mandibular molar", "postoperative pain", "ambulatory orthopedic surgery", "dental phobia" ] }, { "stage": "APPROVAL", "drug": "MEXILETINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Ventricular arrhythmia", "myotonic disorders", "Kennedy disease", "bulbospinal muscular atrophy" ] }, { "stage": "APPROVAL", "drug": "TOPIRAMATE", "drugType": "Small molecule", "indications": [ "epilepsy", "migraine disorder", "Lennox-Gastaut syndrome", "Seizure", "alcohol dependence", "bipolar disorder", "manic episode", "mixed episode", "bipolar I disorder", "partial-onset seizures", "obsessive-compulsive disorder", "obsessive-compulsive problems", "Motor tics", "attention deficit-hyperactivity disorder", "Tourette syndrome", "type 2 diabetes mellitus", "obesity disorder", "inherited lipid metabolism disorder", "generalized tonic-clonic seizure", "essential tremor", "essential hypertension", "primary generalized tonic-clonic seizures", "Generalized-onset seizure", "partial onset seizures", "partial onset epilepsy", "secondarily generalized seizures", "acute manic episode", "Obesity", "gambling behaviour", "cocaine dependence", "tobacco addiction", "nicotine dependence", "binge eating disorder", "Borderline personality disorder", "post-traumatic stress disorder", "Overweight", "polycystic ovary syndrome", "impulsivity", "Polyphagia", "Self-injurious behavior", "Prader-Willi syndrome", "alcohol abuse", "diabetes mellitus", "Uric acid nephrolithiasis", "nephrolithiasis, calcium oxalate", "Calcium oxalate nephrolithiasis", "non-convulsive status epilepticus", "eating disorder", "Addictive alcohol use", "posttraumatic stress disorder", "Epileptic spasm", "orofacial neuropathic pain syndromes", "trigeminal neuralgia", "lumbar radiculopathy", "Sciatica", "smoking cessation", "childhood absence epilepsy", "multiple sclerosis", "cocaine craving", "Abdominal obesity", "diabetic peripheral polyneuropathy", "focal epilepsy", "Focal-onset seizure", "Parkinson disease", "Dyskinesia", "methamphetamine dependence", "problem gambling", "pathological gambling", "cocaine abstinence", "Cannabis use", "brain ischemia", "vascular dysfunction", "heavy drinking", "body mass index reduction", "compulsive buying", "cryptogenic sensory peripheral neuropathy", "metabolic syndrome", "weight regain", "morbid obesity", "ulcerative colitis", "sudden sensorineural hearing loss", "human immunodeficiency virus 1 infection", "human immunodeficiency virus infection", "migraine prophylaxis", "schizoaffective disorder", "Pain", "Rett syndrome", "generalized social phobia", "alcohol withdrawal", "migraine with aura", "generalized tonic-clonic seizures", "cannabis use disorder", "bipolar mania", "medication overuse headache", "problem drinking", "migraine-associated dizziness", "bulimia nervosa", "post-traumatic headache", "chronic migraine", "probable vestibular migraine", "Neuhauser definite vestibular migraine", "non-Neuhauser vestibular migraine", "vestibular migraine", "compulsive sexual behavior", "schizophrenia", "migraine without aura", "obesity-associated comorbidities" ] }, { "stage": "APPROVAL", "drug": "ETIDOCAINE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "APPROVAL", "drug": "ENCAINIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "complex ventricular arrhythmia", "heart arrhythmia" ] }, { "stage": "APPROVAL", "drug": "ESLICARBAZEPINE ACETATE", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "partial onset seizures", "focal epilepsy", "Focal-onset seizure", "simple partial seizures", "Focal impaired awareness seizure", "post-herpetic neuralgia", "diabetic neuropathic pain", "partial-onset seizures", "diabetic neuropathy", "fibromyalgia", "acute manic episode", "acute mania", "bipolar I disorder", "partial-onset epilepsy" ] }, { "stage": "APPROVAL", "drug": "HEXYLCAINE", "drugType": "Small molecule", "indications": [ "anaesthesia" ] }, { "stage": "APPROVAL", "drug": "LACOSAMIDE", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "convulsion", "focal epilepsy", "diabetic neuropathy", "secondarily generalized tonic-clonic seizures", "Focal-onset seizure", "neuropathic pain", "partial-onset seizures", "distal diabetic neuropathy", "breakthrough seizures", "generalized tonic-clonic seizures", "primary erythermalgia", "partial onset seizures", "epilepsy with partial-onset seizures", "primary generalized tonic-clonic seizures", "idiopathic generalized epilepsy", "generalized onset tonic-clonic seizures", "Bilateral tonic-clonic seizure", "status epilepticus", "non-convulsive status epilepticus", "Sciatica", "migraine disorder", "bipolar disorder", "major depressive episode", "postherpetic neuralgia", "fibromyalgia", "osteoarthritis, knee", "peripheral diabetic neuropathy", "primary generalized epilepsy", "nonconvulsive seizures", "epilepsy syndromes associated with generalized seizures", "peripheral neuropathic pain", "alcohol dependence", "amyotrophic lateral sclerosis", "opioid-induced hyperalgesia", "chronic pancreatitis", "partial-onset epilepsy", "partial onset epilepsy", "cognitive function impairment", "depressive disorder", "Anxiety", "autoimmune-associated epilepsy", "acute symptomatic seizure secondary to autoimmune encephalitis", "acute brain injury", "electrographic status epilepticus", "Coma", "trigeminal neuralgia", "Pain", "Convulsive status epilepticus", "post herpetic neuralgia" ] }, { "stage": "APPROVAL", "drug": "PHENACEMIDE", "drugType": "Small molecule", "indications": [ "epilepsy" ] }, { "stage": "APPROVAL", "drug": "PROCAINAMIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia", "ventricular fibrillation", "Sudden death", "ventricular tachycardia", "atrial fibrillation", "wide QRS tachycardia", "arrhythmic death", "Supraventricular tachycardia" ] }, { "stage": "APPROVAL", "drug": "ORPHENADRINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Parkinson disease" ] }, { "stage": "PHASE_3", "drug": "TETRACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "pulpal anesthesia", "local anesthesia", "corneal abrasion", "maxillary teeth", "acute pain" ] }, { "stage": "PHASE_3", "drug": "PROCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "oral aphthous ulcers", "Oral ulcer", "human immunodeficiency virus infection", "AIDS" ] }, { "stage": "PHASE_3", "drug": "EVENAMIDE", "drugType": "Small molecule", "indications": [ "schizophrenia" ] }, { "stage": "PHASE_3", "drug": "BENOXINATE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "ocular surface anesthesia", "postoperative pain" ] }, { "stage": "PHASE_3", "drug": "PROPARACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "ocular anesthesia", "Vitreous floaters" ] }, { "stage": "PHASE_3", "drug": "MEPIVACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Pain", "perineal laceration", "irreversible pulpitis", "maxillary teeth extraction", "diabetes mellitus", "tooth extraction" ] }, { "stage": "PHASE_3", "drug": "RALFINAMIDE", "drugType": "Small molecule", "indications": [ "neuropathic pain", "post-traumatic lumbar radiculopathy", "neuropathic low back pain", "compression radiculopathy", "post-surgical lumbar radiculopathy" ] }, { "stage": "PHASE_2", "drug": "AFACIFENACIN", "drugType": "Small molecule", "indications": [ "overactive bladder" ] }, { "stage": "PHASE_2", "drug": "NERISPIRDINE", "drugType": "Small molecule", "indications": [ "multiple sclerosis", "spinal cord injury", "visual function impairment" ] }, { "stage": "PHASE_2", "drug": "MORICIZINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "complex ventricular arrhythmia" ] }, { "stage": "PHASE_2", "drug": "PF-04531083", "drugType": "Small molecule", "indications": [ "Pain", "toothache", "heat pain" ] }, { "stage": "PHASE_1", "drug": "DSP-2230", "drugType": "Small molecule", "indications": [ "neuropathic pain" ] }, { "stage": "IND", "drug": "NKTR-171", "drugType": "Unknown", "indications": [ "neuropathic pain" ] }, { "stage": "UNKNOWN", "drug": "DYCLONINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "colonoscopy" ] }, { "stage": "UNKNOWN", "drug": "PRILOCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "spinal anesthesia", "frozen shoulder" ] }, { "stage": "UNKNOWN", "drug": "ENCAINIDE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [] } ] }, "dgidb": { "count": 89, "drugs": [ { "drug": "DYCLONINE", "approved": true, "types": [], "sources": [ "TEND", "TdgClinicalTrial" ] }, { "drug": "ZONISAMIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "FUNAPIDE", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "HEXYLCAINE", "approved": true, "types": [], "sources": [ "TEND", "TdgClinicalTrial" ] }, { "drug": "PROCAINE", "approved": true, "types": [], "sources": [ "TEND", "TdgClinicalTrial" ] }, { "drug": "DRONEDARONE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "NKTR-171", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "LAMOTRIGINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ESLICARBAZEPINE", 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disorder", "tobacco abstinence", "pathological gambling", "tobacco smoking addiction", "bipolar mood disorders", "smoking tobacco dependence", "tobacco dependence", "tobacco smoking dependence", "cannabis use disorder", "physical activity increase", "food addiction", "human immunodeficiency virus infection", "suboptimal weight loss", "generalized anxiety disorder", "pulmonary tuberculosis", "weight regain", "obesity-associated comorbidities", "active smoking", "weight management" ] }, { "stage": "APPROVAL", "drug": "PHENMETRAZINE", "drugType": "Small molecule", "indications": [ "Obesity" ] }, { "stage": "APPROVAL", "drug": "METHAMPHETAMINE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "Pain", "stimulant use disorder", "obsessive-compulsive disorder", "methamphetamine dependence", "opioid use disorder", "methamphetamine addiction" ] }, { "stage": "APPROVAL", "drug": "METHYLPHENIDATE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "narcolepsy-cataplexy syndrome", "Hyperactivity", "major depressive disorder", "nicotine dependence", "substance use disorder", "asthenia", "Fatigue", "brain neoplasm", "autism spectrum disorder", "delirium", "sickle cell disease", "distress", "somatic complaints", "Anxiety", "bipolar disorder", "memory loss", "HIV-associated neurocognitive disorder", "Alzheimer disease", "Apathy", "substance use", "attention-deficit disorder", "Obesity", "multiple sclerosis", "cancer related fatigue", "Cannabis use", "cancer-related fatigue", "mood disorder", "excessive daytime sleepiness", "myotonic dystrophy type 1", "vascular cognitive impairment", "Sleep disturbance", "cocaine dependence", "neurocognitive sequelae", "depressive disorder", "Parkinson disease", "smoking abstinence", "tobacco dependence", "aggressive behavior", "severe mood dysregulation", "Irritability", "methamphetamine dependence", "traumatic brain injury", "posttraumatic stress disorder", "binge eating disorder", "neuropsychological deficits", "brain injury", "deficits in neuropsychological function", "multiple sclerosis fatigue", "Gulf War Illness", "cancer-related cognitive impairment", "cognitive function impairment", "cognitive disorder", "post-traumatic stress disorder", "childhood apraxia of speech", "Chronic pain", "schizophrenia spectrum illness", "schizophrenia", "type 1 diabetes mellitus", "alcohol abuse", "opiate dependence", "general anesthesia", "attention deficit disorder", "conduct disorder", "propofol sedation", "ischemic stroke", "orthostatic hypotension", "emergence from isoflurane general anesthesia", "cocaine use", "disorders of consciousness", "minimally conscious state", "vegetative state", "Coma", "methamphetamine-use disorder", "Intellectual disability", "chronic low back pain", "attention deficits", "executive functioning deficits", "heart failure", "Gait disturbance", "motivation", "cerebral palsy", "cocaine use disorder", "alcohol dependence", "Borderline personality disorder", "anxiety disorder", "distractibility", "impulsiveness", "Tourette syndrome", "memory deficits", "Cognitive impairment", "developmental disorders", "Stroke", "diabetes mellitus", "executive function impairment", "reading difficulties", "response readiness", "episodic memory consolidation", "creativity", "attention problems", "mild cognitive impairment", "behavioral insomnia of childhood", "primary nocturnal enuresis", "dopaminergic dysfunction", "disruptive mood dysregulation disorder", "inattentive children without diagnosis", "Fever", "mild hypothermia", "memory problems", "attentional dysfunction", "22q11.2 deletion syndrome", "impulsive aggression", "inattention", "impulsivity", "chronic irritability", "emotion-behavioral dysregulation" ] }, { "stage": "APPROVAL", "drug": "PHENDIMETRAZINE TARTRATE", "drugType": "Small molecule", "indications": [ "obesity disorder" ] }, { "stage": "APPROVAL", "drug": "DASOTRALINE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "eating disorder", "mood disorder", "major depressive disorder" ] }, { "stage": "APPROVAL", "drug": "DEXTROAMPHETAMINE SACCHARATE", "drugType": "Small molecule", "indications": [ "narcolepsy-cataplexy syndrome", "attention deficit-hyperactivity disorder" ] }, { "stage": "APPROVAL", "drug": "PHENDIMETRAZINE", "drugType": "Small molecule", "indications": [ "Obesity", "cocaine dependence", "cocaine use disorder" ] }, { "stage": "APPROVAL", "drug": "MAZINDOL", "drugType": "Small molecule", "indications": [ "obesity disorder", "Obesity", "excessive daytime sleepiness", "Cataplexy", "narcolepsy-cataplexy syndrome", "cocaine abuse", "attention deficit-hyperactivity disorder", "narcolepsy" ] }, { "stage": "APPROVAL", "drug": "SERDEXMETHYLPHENIDATE CHLORIDE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder" ] }, { "stage": "APPROVAL", "drug": "DEXMETHYLPHENIDATE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder" ] }, { "stage": "APPROVAL", "drug": "MODAFINIL", "drugType": "Small molecule", "indications": [ "narcolepsy-cataplexy syndrome", "obstructive sleep apnea syndrome", "daytime sleepiness", "narcolepsy", "attention deficit-hyperactivity disorder", "postpoliomyelitis syndrome", "excessive sleepiness", "obstructive sleep apnea/hypopnea syndrome", "shift work sleep disorder", "sedation", "brain neoplasm", "cocaine withdrawal", "cocaine dependence", "metastatic breast cancer", "metastatic prostate carcinoma", "Fatigue", "Cataplexy", "Alzheimer disease", "Apathy", "cancer related fatigue", "poststroke fatigue", "stroke disorder", "hypoactive delirium", "multiple sclerosis", "Ewing sarcoma", "depressive disorder", "Cognitive impairment", "cognitive impairment in depression", "major depressive disorder", "post-traumatic stress disorder", "inflammatory bowel disease", "methamphetamine dependence", "alcohol dependence", "cognitive dysfunction", "relapse to drug use", "disease recurrence", "schizoaffective disorder", "schizophrenia", "neglect", "Dysphagia", "malignant epithelial tumor of ovary", "ovarian carcinoma", "excessive daytime sleepiness", "liver metastases", "colorectal carcinoma", "ovarian cancer", "non-small cell lung carcinoma", "fallopian cancer", "primary peritoneal carcinoma", "uterine cancer", "breast cancer", "endometrial cancer", "cervical cancer", "freezing of gait", "Parkinson disease", "cocaine use disorder", "idiopathic hypersomnia", "narcolepsy without cataplexy", "postoperative cognitive dysfunction", "sleep-wake rhythm disturbance", "long COVID-19", "insomnia", "hypersomnia", "postural orthostatic tachycardia syndrome", "schizophrenia spectrum psychosis", "cancer-related fatigue", "cancer-related cognitive impairment", "Low back pain", "orthostatic hypotension", "nicotine dependence", "Tinnitus", "melanoma", "hepatocellular carcinoma", "cocaine abuse", "sleepiness", "sleep deprivation", "cannabis use disorder", "cerebral palsy", "brain injury", "neurobehavioral dysfunction", "healthy subjects", "new learning impairment", "relapsing-remitting multiple sclerosis", "systemic lupus erythematosus", "traumatic brain injury", "working memory impairment", "Impaired glucose tolerance", "type 2 diabetes mellitus", "healthy participants", "general anesthesia related delayed emergence", "dopaminergic dysfunction", "advanced solid tumors", "musculoskeletal complications", "neurocognitive complications", "morbid obesity" ] }, { "stage": "APPROVAL", "drug": "DIETHYLPROPION HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "obesity disorder" ] }, { "stage": "APPROVAL", "drug": "LISDEXAMFETAMINE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "attention deficits", "eating disorder", "bipolar disorder", "obesity disorder", "cocaine dependence", "multiple sclerosis", "severe mood dysregulation", "sluggish cognitive tempo", "methamphetamine use disorder", "type 1 diabetes mellitus", "methamphetamine dependence", "Obesity", "nicotine dependence", "cognitive dysfunction", "cognitive difficulties", "verbal memory decline", "executive function complaints", "executive function difficulties", "autism spectrum disorder", "attention deficit disorders" ] }, { "stage": "APPROVAL", "drug": "ARMODAFINIL", "drugType": "Small molecule", "indications": [ "narcolepsy-cataplexy syndrome", "sleep disorder", "obstructive sleep apnea syndrome", "childhood malignant neoplasm", "attention deficit-hyperactivity disorder", "obstructive sleep apnea/hypopnea syndrome", "chronic shift work sleep disorder", "narcolepsy", "excessive sleepiness", "shift work sleep disorder", "excessive sleepiness associated with jet lag disorder", "binge eating disorder", "major depressive disorder", "bipolar I disorder", "major depressive episode", "cancer-related fatigue", "plasma cell myeloma", "postoperative recovery", "obesity disorder", "sarcoidosis", "multiple sclerosis", "daytime sleepiness", "schizophrenia", "Cognitive impairment", "Fatigue", "insomnia", "stroke disorder", "sleep deprivation", "excessive sleepiness associated with shift work disorder", "Lewy body dementia", "Parkinson disease", "sleep apnea syndrome" ] }, { "stage": "APPROVAL", "drug": "METHAMPHETAMINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder" ] }, { "stage": "APPROVAL", "drug": "AMPHETAMINE SULFATE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "narcolepsy-cataplexy syndrome", "obesity disorder", "cocaine dependence", "Stroke" ] }, { "stage": "APPROVAL", "drug": "BUPROPION HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "major depressive disorder", "depressive disorder", "mood disorder", "non-small cell lung carcinoma", "attention deficit-hyperactivity disorder", "cancer related fatigue", "cocaine dependence", "smoking cessation", "sexual dysfunction", "sexual desire dysfunction", "squamous cell cancer of the head and neck", "nicotine dependence", "chronic periodontitis", "weight regain", "inadequate weight loss", "head and neck squamous cell carcinoma" ] }, { "stage": "APPROVAL", "drug": "METHYLPHENIDATE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "Alzheimer disease", "Huntington disease", "Fatigue", "excessive daytime sleepiness", "Sleep disturbance", "Pain", "myalgic encephalomeyelitis/chronic fatigue syndrome", "fetal alcohol spectrum disorder" ] }, { "stage": "APPROVAL", "drug": "AMPHETAMINE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "externalizing symptoms", "cocaine dependence", "Cognitive impairment", "processing speed impairment", "multiple sclerosis", "cannabis use disorder", "neurocognitive sequelae", "depressive disorder", "cocaine use disorder", "autism spectrum disorder", "schizophrenia", "osteoarthritis of the basal thumb joint", "bipolar phenotype", "major depressive disorder", "reading difficulties", "impulsive aggression", "chronic irritability" ] }, { "stage": "APPROVAL", "drug": "DEXMETHYLPHENIDATE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "Fatigue" ] }, { "stage": "APPROVAL", "drug": "DEXTROAMPHETAMINE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "arteriosclerosis disorder", "drug dependence", "narcolepsy", "narcolepsy-cataplexy syndrome", "cocaine dependence", "opiate dependence", "Stroke", "neurocognitive sequelae", "depressive disorder", "methamphetamine dependence", "motor function recovery", "ischemic stroke", "Aphasia", "schizophrenia", "schizoaffective disorder", "bipolar disorder", "opioid use disorder", "cocaine use disorder", "post-traumatic stress disorder", "obsessive-compulsive disorder" ] }, { "stage": "APPROVAL", "drug": "DEXTROAMPHETAMINE SULFATE", "drugType": "Small molecule", "indications": [ "narcolepsy-cataplexy syndrome", "attention deficit-hyperactivity disorder", "severe fatigue", "paraganglioma", "cocaine dependence", "opiate dependence", "depressive disorder", "fetal alcohol spectrum disorder" ] }, { "stage": "APPROVAL", "drug": "BUPROPION HYDROBROMIDE", "drugType": "Small molecule", "indications": [ "major depressive disorder" ] }, { "stage": "APPROVAL", "drug": "DIETHYLPROPION", "drugType": "Small molecule", "indications": [ "obesity disorder", "migraine disorder", "Obesity", "extreme obesity", "obesity-associated comorbidities" ] }, { "stage": "APPROVAL", "drug": "SIBUTRAMINE", "drugType": "Small molecule", "indications": [ "obesity disorder", "Obesity", "binge eating disorder", "Overweight", "hypertensive disorder", "post-cessation weight gain", "cigarette smoking", "extreme obesity", "alimentary obesity" ] }, { "stage": "PHASE_3", "drug": "CENTANAFADINE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "Anxiety", "smoking abstinence", "binge eating disorder", "major depressive disorder" ] }, { "stage": "PHASE_3", "drug": "AMITIFADINE", "drugType": "Small molecule", "indications": [ "Obesity", "major depressive disorder", "alcohol dependence", "mood disorder" ] }, { "stage": "PHASE_3", "drug": "AMPHETAMINE ASPARTATE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder" ] }, { "stage": "PHASE_3", "drug": "SERDEXMETHYLPHENIDATE", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "idiopathic hypersomnia" ] }, { "stage": "PHASE_3", "drug": "BICIFADINE", "drugType": "Small molecule", "indications": [ "chronic low back pain", "neuropathic pain", "Low back pain", "diabetic neuropathy", "peripheral neuropathic pain" ] }, { "stage": "PHASE_3", "drug": "MIDOMAFETAMINE", "drugType": "Small molecule", "indications": [ "post-traumatic stress disorder", "posttraumatic stress disorder", "moral injury", "alcohol abuse", "Anxiety", "cancer", "depressive disorder", "social anxiety", "binge eating disorder", "anorexia nervosa", "social phobia", "opioid use disorder", "post-traumatic stress", "adjustment disorder", "alcohol dependence", "obsessive-compulsive disorder", "Borderline personality disorder", "neuropathic pain", "autism spectrum disorder", "schizophrenia", "mental well-being", "hyperalgesia", "allodynia", "acute nociceptive pain", "bulimia nervosa", "fibromyalgia", "pathological narcissism", "wellness", "mood disorder", "Pain" ] }, { "stage": "PHASE_2", "drug": "LIAFENSINE", "drugType": "Small molecule", "indications": [ "major depressive disorder", "treatment resistant depression", "depressive disorder" ] }, { "stage": "PHASE_2", "drug": "TESOFENSINE", "drugType": "Small molecule", "indications": [ "Pain", "Dyskinesia", "Parkinson disease", "dementia of the Alzheimer's type", "obesity disorder", "type 2 diabetes mellitus", "Prader-Willi syndrome", "Obesity" ] }, { "stage": "PHASE_2", "drug": "NS-2359", "drugType": "Small molecule", "indications": [ "attention deficit-hyperactivity disorder", "cocaine dependence", "mood disorder", "major depressive disorder", "cocaine abstinence" ] }, { "stage": "PHASE_2", "drug": "TEDATIOXETINE", "drugType": "Small molecule", "indications": [ "major depressive disorder", "generalized anxiety disorder" ] }, { "stage": "UNKNOWN", "drug": "NOMIFENSINE MALEATE", "drugType": "Small molecule", "indications": [] }, { "stage": "UNKNOWN", "drug": "SIBUTRAMINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [] }, { "stage": "UNKNOWN", "drug": "PYROVALERONE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [] } ] }, "dgidb": { "count": 72, "drugs": [ { "drug": "DASOTRALINE", "approved": false, "types": [ "inhibitor" ], "sources": [ "TTD", "ChEMBL" ] }, { "drug": "MAZINDOL", "approved": true, "types": [ "inhibitor", "inhibitor" ], "sources": [ "GuideToPharmacology", "ChEMBL" ] }, { "drug": "BUPROPION HYDROBROMIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "SIBUTRAMINE", "approved": false, "types": [ "inhibitor" ], "sources": [ "TdgClinicalTrial", "GuideToPharmacology" ] }, { "drug": "METHYLPHENIDATE", "approved": true, "types": [ "inhibitor", "inhibitor" ], "sources": [ "TEND", "TdgClinicalTrial", "GuideToPharmacology", "TTD", "ChEMBL" ] }, { "drug": "3,4-METHYLENEDIOXYMETHAMPHETAMINE", "approved": false, "types": [ "other/unknown" ], "sources": [ "TTD", "ChEMBL" ] }, { "drug": "LISDEXAMFETAMINE DIMESYLATE", "approved": true, "types": [], "sources": [ "TEND", "TdgClinicalTrial" ] }, { "drug": "TESOFENSINE", "approved": false, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "PHENDIMETRAZINE TARTRATE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "LEVOMILNACIPRAN", "approved": true, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "BUPROPION HYDROCHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "TEND", "TdgClinicalTrial", "GuideToPharmacology" ] }, { "drug": "AMPHETAMINE ADIPATE", "approved": true, "types": [ "other/unknown" ], "sources": [ "ChEMBL" ] }, { "drug": "ANESTHETIC AGENT", "approved": false, "types": [], "sources": [ "NCI" ] }, { "drug": "TRIMIPRAMINE", "approved": true, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "AMPHETAMINE ASPARTATE", "approved": true, "types": [ "other/unknown" ], "sources": [ "ChEMBL" ] }, { "drug": "RTI-336", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "HINOKININ", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "[3H]GBR12935", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "METYROSINE", "approved": true, "types": [], "sources": [ "NCI" ] }, { "drug": "DIETHYLPROPION HYDROCHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "CLOMIPRAMINE", "approved": true, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "SERDEXMETHYLPHENIDATE CHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "METHYLPHENIDATE HYDROCHLORIDE", "approved": true, "types": [], "sources": [ "NCI" ] }, { "drug": "PHENMETRAZINE", "approved": true, "types": [], "sources": [ "TEND", "TdgClinicalTrial", "TTD" ] }, { "drug": "CLOZAPINE", "approved": true, "types": [], "sources": [ "PharmGKB" ] }, { "drug": "COMPOUND 58 [PMID: 25037917]", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "SOLRIAMFETOL", "approved": true, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "ALTROPANE", "approved": false, "types": [], "sources": [ "TdgClinicalTrial", "TTD" ] }, { "drug": "TOLUDESVENLAFAXINE", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "DEXTROAMPHETAMINE SACCHARATE", "approved": true, "types": [ "other/unknown" ], "sources": [ "ChEMBL" ] }, { "drug": "PYROVALERONE HYDROCHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "DESVENLAFAXINE SUCCINATE", "approved": true, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "PHENTERMINE RESIN", "approved": true, "types": [], "sources": [ "TEND", "TdgClinicalTrial" ] }, { "drug": "AMITIFADINE HYDROCHLORIDE", "approved": false, "types": [], "sources": [ "TdgClinicalTrial", "TTD" ] }, { "drug": "PHENELZINE", "approved": true, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "BICIFADINE", "approved": false, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "PSEUDOEPHEDRINE POLISTIREX", "approved": true, "types": [], "sources": [ "TdgClinicalTrial" ] }, { "drug": "PHENMETRAZINE HYDROCHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "DEXTROAMPHETAMINE ADIPATE", "approved": true, "types": [ "other/unknown" ], "sources": [ "ChEMBL" ] }, { "drug": "NOMIFENSINE", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "NS-2359", "approved": false, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "LEVODOPA", "approved": true, "types": [], "sources": [ "PharmGKB" ] }, { "drug": "SIBUTRAMINE HYDROCHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "ATOMOXETINE HYDROCHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "IOFLUPANE I-123", "approved": true, "types": [], "sources": [ "TTD" ] }, { "drug": "TEDATIOXETINE", "approved": false, "types": [], "sources": [ "TdgClinicalTrial" ] }, { "drug": "ALTROPANE I-123", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "CENTANAFADINE", "approved": false, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "AMPHETAMINE SULFATE", "approved": true, "types": [], "sources": [ "NCI" ] }, { "drug": "DEXTROAMPHETAMINE SULFATE", "approved": true, "types": [ "other/unknown" ], "sources": [ "ChEMBL" ] }, { "drug": "DISULFIRAM", "approved": true, "types": [], "sources": [ "PharmGKB" ] }, { "drug": "ACETYLCYSTEINE", "approved": true, "types": [], "sources": [ "NCI" ] }, { "drug": "[3H]WIN35428", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "METHAMPHETAMINE HYDROCHLORIDE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "SERDEXMETHYLPHENIDATE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "BENZTROPINE", "approved": true, "types": [], "sources": [ "TEND", "TdgClinicalTrial" ] }, { "drug": "SPIROGLUMIDE", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "AMITIFADINE", "approved": false, "types": [ "inhibitor" ], "sources": [ 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FD17 PET Imaging of \u03b1-synuclein: A Clinical Study in \u03b1-synucleinopathy Patients", "status": "COMPLETED", "phases": [] } ] }, "auto_flag": "clinical" }, { "gene": "COL10A1", "ensembl": "ENSG00000123500", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "ROS1", "ensembl": "ENSG00000047936", "errors": [], "open_targets": { "count": 4, "rows": [ { "stage": "APPROVAL", "drug": "CRIZOTINIB", "drugType": "Small molecule", "indications": [ "non-small cell lung carcinoma", "neoplasm", "non-small cell squamous lung carcinoma", "cancer", "anaplastic lymphoma kinase-positive non-small cell lung cancer", "inflammatory myofibroblastic tumor", "uveal melanoma", "clear cell sarcoma", "anaplastic large cell lymphoma", "hepatocarcinoma", "breast cancer", "colorectal cancer", "clear cell renal carcinoma", "cholangiocarcinoma", "rhabdomyosarcoma", "glioblastoma", "neuroblastoma", "gastric cancer", "medullary thyroid gland carcinoma", "thyroid gland undifferentiated (anaplastic) carcinoma", "ovarian cancer", "thyroid gland papillary carcinoma", "papillary renal cell carcinoma", "thyroid gland follicular carcinoma", "disease progression", "triple-negative breast carcinoma", "lung adenocarcinoma", "lymphoma", "gastric adenocarcinoma", "solid tumor", "plasma cell myeloma", "urothelial cancer", "acute myeloid leukemia", "kidney cancer", "extrahepatic cholangiocarcinoma", "gallbladder carcinoma", "advanced solid tumor", "non-Hodgkin lymphoma", "thyroid gland carcinoma", "hereditary diffuse gastric adenocarcinoma", "estrogen-receptor positive breast cancer", "Familial gastric cancer", "endometrial cancer", "NF2-related schwannomatosis", "Vestibular schwannoma", "rare solid tumors", "squamous cell lung carcinoma", "cutaneous melanoma", "lung cancer", "bone cancer", "non-small cell lung adenocarcinoma", "tumors with genetic events 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"central nervous system cancer", "digestive system neoplasm", "solid tumor", "tumor response", "progression free survival", "thyroid gland undifferentiated (anaplastic) carcinoma", "medullary thyroid gland carcinoma", "thyroid gland papillary carcinoma", "thyroid cancer", "thyroid gland follicular carcinoma", "poorly differentiated thyroid gland carcinoma", "malignant glioma", "rare tumours", "extracranial solid tumor", "primary brain neoplasm", "uveal melanoma", "mammary analogue secretory carcinoma", "neuroblastoma", "solid tumours", "malignant pancreatic neoplasm", "prostate cancer", "hematopoietic and lymphoid cell neoplasm", "acute myeloid leukemia", "ovarian cancer", "sarcoma", "metastatic solid tumor", "locally advanced solid tumor" ] }, { "stage": "APPROVAL", "drug": "REPOTRECTINIB", "drugType": "Small molecule", "indications": [ "non-small cell lung carcinoma", "cancer", "neoplasm", "brain metastasis", "hormone receptor-positive human epidermal growth factor 2-negative 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{ "drug": "CERITINIB", "approved": true, "types": [], "sources": [ "CGI", "CKB-CORE", "CIViC" ] }, { "drug": "SNS-314", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "LORLATINIB", "approved": true, "types": [ "inhibitor" ], "sources": [ "PharmGKB", "CGI", "CKB-CORE", "GuideToPharmacology", "CIViC", "FDA", "TTD" ] }, { "drug": "REPOTRECTINIB", "approved": true, "types": [ "inhibitor" ], "sources": [ "PharmGKB", "CKB-CORE", "GuideToPharmacology", "CIViC", "TTD" ] }, { "drug": "CABOZANTINIB S-MALATE", "approved": true, "types": [], "sources": [ "CGI", "CKB-CORE", "CIViC" ] }, { "drug": "JNJ-7706621", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "PROCYSTEINE", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "PEMBROLIZUMAB", "approved": true, "types": [], "sources": [ "CKB-CORE" ] }, { "drug": "ILORASERTIB", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "NEFLAMAPIMOD", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "RG-1530", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "ALISERTIB", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "CEMIPLIMAB", "approved": true, "types": [], "sources": [ "PharmGKB" ] }, { "drug": "BATOPROTAFIB", "approved": false, "types": [], "sources": [ "CKB-CORE" ] }, { "drug": "CP-547632", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "ALECTINIB", "approved": true, "types": [], "sources": [ "CKB-CORE" ] }, { "drug": "AST-487", "approved": false, "types": [], "sources": [ "DTC" ] }, { "drug": "ERLOTINIB", "approved": true, "types": [], "sources": [ "CKB-CORE" ] }, { "drug": "HESPERADIN", "approved": false, "types": [ "inhibitor" ], "sources": [ "DTC" ] }, { "drug": "GEFITINIB", "approved": true, "types": [], "sources": [ "CKB-CORE" ] }, { "drug": "ALK/C-MET INHIBITOR TQ-B3139", "approved": false, "types": [], "sources": [ "CKB-CORE" ] }, { "drug": "GILTERITINIB", "approved": true, "types": [ 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"ALK INHIBITOR TAE684", "approved": false, "types": [], "sources": [ "CIViC" ] }, { "drug": "SODIUM PYRUVATE", "approved": true, "types": [], "sources": [ "TTD" ] }, { "drug": "ASP-3026", "approved": false, "types": [ "inhibitor" ], "sources": [ "CancerCommons" ] } ], "approved": [ "AFATINIB", "ALECTINIB", "BRIGATINIB", "CABOZANTINIB S-MALATE", "CARBOPLATIN", "CEMIPLIMAB", "CERITINIB", "CRIZOTINIB", "ENTRECTINIB", "ERLOTINIB", "GEFITINIB", "GILTERITINIB", "LORLATINIB", "OSIMERTINIB", "PACLITAXEL PROTEIN-BOUND", "PEMBROLIZUMAB", "PEMETREXED DISODIUM", "REPOTRECTINIB", "SELUMETINIB", "SODIUM PYRUVATE", "TAFENOQUINE" ] }, "clinicaltrials": { "count": 267, "top": [ { "nct": "NCT04591431", "title": "The Rome Trial From Histology to Target: the Road to Personalize Target Therapy and Immunotherapy", "status": "UNKNOWN", "phases": [ "PHASE2" ] }, { "nct": "NCT04989322", "title": "Pembrolizumab, Lenvatinib and Chemotherapy After TKIs in NSCLC", "status": "UNKNOWN", "phases": [ "PHASE2" ] }, { "nct": "NCT06140836", "title": "A Study of Repotrectinib Versus Crizotinib in Participants With Locally Advanced or Metastatic Tyrosine Kinase Inhibitor (TKI)-na\u00efve ROS1-positive Non-Small Cell Lung Cancer (NSCLC) (TRIDENT-3)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE3" ] } ] }, "auto_flag": "clinical" }, { "gene": "TEX15", "ensembl": "ENSG00000133863", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "CRYBA4", "ensembl": "ENSG00000196431", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "PAEP", "ensembl": "ENSG00000122133", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 3, "drugs": [ { "drug": "CYPROTERONE ACETATE", "approved": false, "types": [], "sources": [ "NCI" ] }, { "drug": "GENISTEIN", "approved": true, "types": [], "sources": [ "NCI" ] }, { "drug": "DOCOSANOL", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] } ], "approved": [ "DOCOSANOL", "GENISTEIN" ] }, "clinicaltrials": { "count": 16, "top": [ { "nct": "NCT06971822", "title": "Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults", "status": "RECRUITING", "phases": [ "NA" ] }, { "nct": "NCT02081651", "title": "Parmigiano-Reggiano Cheese as a Possible Strategy to Acquire Oral Tolerance in Children With Cow's Milk Allergy", "status": "UNKNOWN", "phases": [ "PHASE3" ] }, { "nct": "NCT04872868", "title": "Long-term Effect of a 3-month Supplementation With Holo-BLG on House Dust Mite Induced Allergic Rhinoconjunctivitis", "status": "COMPLETED", "phases": [] } ] }, "auto_flag": "review" }, { "gene": "DCC", "ensembl": "ENSG00000187323", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 333, "top": [ { "nct": "NCT05785611", "title": "A Study Evaluating the Effect of Filgotinib in Participants With Active Axial Spondyloarthritis", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE3" ] }, { "nct": "NCT05884736", "title": "Confirming Permanent Lack of Blood Flow to the Brain During A-NRP DCC Organ Transplant", "status": "RECRUITING", "phases": [] }, { "nct": "NCT03315663", "title": "Personalized Smartphone-assisted Coaching System to Improve Glucose Homeostasis in Adults With Prediabetes - Main Study", "status": "WITHDRAWN", "phases": [ "NA" ] } ] }, "auto_flag": "none" }, { "gene": "IGF2BP1", "ensembl": "ENSG00000159217", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "MC5R", "ensembl": "ENSG00000176136", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 12, "drugs": [ { "drug": "SHU9119", "approved": false, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "MT-II", "approved": false, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "BREMELANOTIDE", "approved": true, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "CORTICOTROPIN", "approved": true, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "AGOUTI-RELATED PROTEIN", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "HS024", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "AC-C[CYS-GLU-HIS-D-PHE-ARG-TRP-D-CYS]-PRO-PRO-LYS-ASP-NH2", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "PG-901", "approved": false, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "AFAMELANOTIDE", "approved": true, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "Α-MSH", "approved": false, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "SETMELANOTIDE", "approved": false, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "[125I]NDP-MSH", "approved": false, "types": [ "agonist" ], "sources": [ "GuideToPharmacology" ] } ], "approved": [ "AFAMELANOTIDE", "BREMELANOTIDE", "CORTICOTROPIN" ] }, "clinicaltrials": { "count": 2, "top": [ { "nct": "NCT01450852", "title": "Strength Training Induced Alterations in Markers of Immune Function", "status": "COMPLETED", "phases": [ "NA" ] }, { "nct": "NCT06293664", "title": "Protocol for Alpha MSH Infusion Study in Patients With Type 2 Diabetes", "status": "UNKNOWN", "phases": [ "NA" ] } ] }, "auto_flag": "review" }, { "gene": "ELFN1", "ensembl": "ENSG00000225968", "errors": [], "open_targets": { "count": 0, "rows": [] }, "dgidb": { "count": 0, "drugs": [], "approved": [] }, "clinicaltrials": { "count": 0, "top": [] }, "auto_flag": "none" }, { "gene": "SCN9A", "ensembl": "ENSG00000169432", "errors": [], "open_targets": { "count": 79, "rows": [ { "stage": "APPROVAL", "drug": "PROPAFENONE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "atrial fibrillation", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "MORICIZINE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Arrhythmia", "atrial fibrillation", "complex ventricular arrhythmia", "heart arrhythmia" ] }, { "stage": "APPROVAL", "drug": "FOSPHENYTOIN", "drugType": "Small molecule", "indications": [ "epilepsy", "IgA glomerulonephritis", "status epilepticus", "non-convulsive status epilepticus", "nonconvulsive seizures", "Pain", "herpes zoster", "trigeminal neuralgia", "acute brain injury" ] }, { "stage": "APPROVAL", "drug": "ROPIVACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Pain", "glenohumeral arthritis", "brachial plexus block", "intrapartum pain", "labour pain", "acute pain" ] }, { "stage": "APPROVAL", "drug": "DISOPYRAMIDE PHOSPHATE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "BENOXINATE", "drugType": "Small molecule", "indications": [ "Pruritus", "anaesthesia", "myopia" ] }, { "stage": "APPROVAL", "drug": "DISOPYRAMIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia", "atrial fibrillation", "Urinary incontinence" ] }, { "stage": "APPROVAL", "drug": "PROCAINAMIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia", "ventricular fibrillation", "Sudden death", "ventricular tachycardia", "atrial fibrillation", "wide QRS tachycardia", "arrhythmic death", "Supraventricular tachycardia" ] }, { "stage": "APPROVAL", "drug": "PROPAFENONE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "tachyarrhythmias", "ventricular fibrillation", "atrial fibrillation", "outflow tract ventricular arrhythmias", "supraventricular arrhythmias", "ventricular ectopy" ] }, { "stage": "APPROVAL", "drug": "PHENACEMIDE", "drugType": "Small molecule", "indications": [ "epilepsy" ] }, { "stage": "APPROVAL", "drug": "ETHOTOIN", "drugType": "Small molecule", "indications": [ "Seizure", "Focal impaired awareness seizure", "epilepsy" ] }, { "stage": "APPROVAL", "drug": "PHENYTOIN", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "hypomanic symptoms", "memory impairment", "febrile status epilepticus", "Convulsive status epilepticus", "malignant pancreatic neoplasm", "invasive ductal breast carcinoma", "pancreatic ductal adenocarcinoma", "exocrine pancreatic carcinoma", "neuropathic pain", "polyneuropathy", "gingival recession", "prostate cancer", "human immunodeficiency virus infection", "optic neuritis", "nodding syndrome", "surgical wounds", "Ewing sarcoma", "sarcoma", "non-malignant disorder", "malignant disorder", "cocaine use disorder", "injury", "chronic anal fissure", "Anal fissure", "bronchial asthma", "impulsive aggression", "post-traumatic stress disorder", "subarachnoid hemorrhage", "Anal fistula", "osteonecrosis of the mandible", "osteonecrosis of the jaw", "status epilepticus", "atrophic acne scars" ] }, { "stage": "APPROVAL", "drug": "QUINIDINE SULFATE", "drugType": "Small molecule", "indications": [ "Alzheimer disease", "probable Alzheimer's disease", "Agitation", "dementia", "dementia of the Alzheimer's type", "schizophrenia", "neurobehavioral disorder", "Parkinson disease", "autism spectrum disorder", "major depressive disorder", "disinhibition syndrome", "amyotrophic lateral sclerosis", "Pain", "neurobehavioral manifestations", "pseudobulbar affect" ] }, { "stage": "APPROVAL", "drug": "ORPHENADRINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Parkinson disease" ] }, { "stage": "APPROVAL", "drug": "RUFINAMIDE", "drugType": "Small molecule", "indications": [ "tonic and atonic seizures", "Seizure", "Lennox-Gastaut syndrome", "epilepsy", "pediatric lennox-gastaut syndrome", "Focal-onset seizure", "generalized anxiety disorder", "neuropathic pain", "Chronic pain" ] }, { "stage": "APPROVAL", "drug": "ARTICAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "nerve", "Pain", "irreversible pulpitis", "pulpal anesthesia", "skin anesthesia", "acne scars", "traumatic scars", "local anesthesia", "maxillary tooth extraction", "tooth extraction", "dental phobia" ] }, { "stage": "APPROVAL", "drug": "DRONEDARONE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "atrial fibrillation" ] }, { "stage": "APPROVAL", "drug": "OXCARBAZEPINE", "drugType": "Small molecule", "indications": [ "epilepsy", "Seizure", "focal epilepsy", "Focal-onset seizure", "aggressive behavior", "Agitation", "partial onset seizures", "partial onset epilepsy", "localization related epilepsy", "neuropathic pain", "schizophreniform disorder", "schizophrenia", "multiple sclerosis", "cancer pain", "autism", "peripheral neuropathic pain", "compulsive sexual behavior", "bipolar disorder", "trigeminal neuralgia" ] }, { "stage": "APPROVAL", "drug": "PROPARACAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "corneal abrasion", "myopia", "primary angle closure", "primary angle-closure glaucoma" ] }, { "stage": "APPROVAL", "drug": "INDECAINIDE", "drugType": "Small molecule", "indications": [ "dysrhythmias" ] }, { "stage": "APPROVAL", "drug": "ROPIVACAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "fetal growth restriction", "preeclampsia", "unilateral lower limb surgery", "phantom limb pain", "Pain", "postoperative pain", "cancer recurrence", "colorectal cancer", "post-operative pain", "post operative nausea and vomiting", "catheter-related bladder discomfort", "myofascial syndrome", "chronic pelvic pain", "knee arthroscopy", "ovarian cancer", "labour pain", "diaphragmatic dysfunction", "pulmonary complications", "distal upper limb surgery", "supraclavicular brachial plexus block", "Peripheral arterial stenosis", "unplanned caesarean section", "post-surgical pain", "perineal pain", "post-episiotomy perineal pain", "upper limb surgery", "post-sternotomy pain", "ovarian carcinoma", "malignant epithelial tumor of ovary", "hemi-diaphragmatic paresis", "rebound pain", "Low back pain", "postoperative urinary retention", "labor pain", "postoperative recovery", "omalagia", "cesarean section", "Anxiety", "postpartum pelvic floor disorder", "postpartum depression", "surgical operations", "achilles tendinopathy", "rotator cuff syndrome", "shoulder arthroplasty", "anesthesia", "acute postoperative pain", "local anesthetic systemic toxicity", "neurologic toxicity", "posterior eye surgery", "shoulder surgery", "malignant pancreatic neoplasm", "kidney stone pain", "posttraumatic stress disorder", "Headache", "breast augmentation", "abdominoplasty", "laparoscopy-assisted open ventral hernia repair", "bunionectomy", "total knee arthroplasty", "chronic polypous rhinosinusitis", "chronic rhinosinusitis", "Inguinal hernia", "postoperative fatigue", "dental anesthesia", "upper extremity vascular hemodynamic impairment", "vasodilatation", "squamous hyperplasia", "lichen sclerosus et atrophicus", "rib fracture", "lacertus fibrosus syndrome", "ulnar nerve compression", "stub finger", "Dupuytren Contracture", "carpal tunnel syndrome", "Chronic pain", "postoperative delirium", "postoperative cognitive dysfunction", "post-traumatic stress disorder", "lower limb joint damage", "lower back surgery", "third molar extraction surgery", "upper extremity orthopedic surgery", "subgluteal sciatic nerve block", "pain after surgery", "residual pain", "stump pain", "posterior vaginal wall prolapse", "hyperalgesia", "regional anesthesia", "emergency caesarean section", "post-cesarean pain", "mobilization delay after total hip arthroplasty", "opioid consumption", "supracondylar elbow fracture", "infraclavicular brachial plexus block", "hemodynamic changes", "osteoarthritis", "neurologic injury", "distal sciatic nerve block", "nerve damage", "post-thoracotomy pain", "carotid endarterectomy", "intraoperative pain", "residual limb pain", "upper extremity surgery", "operative anesthesia", "Knee pain", "outpatient laparoscopy", "laparoscopic gynecological surgery", "adverse events", "phrenic nerve blockade", "ipsilateral hemidiaphragm paresis", "pulmonary dysfunction", "spinal anesthesia", "brachial plexus block", "carotid artery surgery", "upper limb orthopedic surgery", "proximal femur fracture", "hip fracture", "delirium", "acute pain", "cholelithiasis", "Cholecystitis", "biliary dyskinesia", "upper limb surgical anesthesia", "hip surgery", "cesarean delivery", "post-operative major complications", "Hallux valgus", "pain after total abdominal hysterectomy", "arteriovenous fistula", "acute kidney injury", "ventral hernia", "medial leg surgery", "medial foot surgery", "medial ankle surgery", "vascular access surgery of the upper arm", "post-surgery pain", "surgical delivery", "postoperative shoulder pain", "cataract", "post-video-assisted thoracotomy pain", "femur fracture", "aneurysm", "breast cancer", "hemidiaphragmatic paralysis", "hemidiaphragmatic paresis", "postoperative abdominal pain", "cerebral palsy", "post-laparoscopic cholecystectomy pain", "motor block", "nerve block", "formarm or hand surgery", "ocular surgery", "open radical cystectomy", "radical retropubic prostatectomy", "pelvic urologic surgery", "lack of muscle relaxation", "hypotensive disorder", "Horner syndrome", "postoperative sore throat", "abdominal bone flap cranioplasty", "epidermolysis bullosa", "pain with movement", "pain at rest", "chronic post-surgical pain", "proximal femoral fractures", "post-craniotomy pain", "spinal anaesthesia", "Increased intracranial pressure", "pain following breast surgery", "postherniorrhaphy pain", "neuropathic pain", "catheter related bladder discomfort syndrome", "femoral shaft fractures", "multiple precancerous colon polyps", "inflammatory bowel disease", "malignant colon neoplasm", "acute gastrointestinal injury", "quadriceps muscle weakness", "positional pain", "pertrochanteric femoral fracture", "functional recovery", "osteoarthritis, knee", "gastric cancer", "chronic post-thoracotomy pain", "perioperative neurocognitive dysfunction", "chronic low-back pain", "pain following shoulder arthroplasty", "spastic paresis", "abdominal neoplasia", "lumbar spine surgery", "neonatal depression", "shoulder pathology", "knee arthroplasty", "Dilatation of the cerebral artery", "obstetric perineal lacerations", "meniscal tear", "heart failure with reduced ejection fraction", "visceral pain", "osteoarthritis, hip", "persistent pain post mastectomy", "symptomatic hip dysplasia", "congenital pulmonary cystic disease", "open lumbar infrarenal aortic aneurysm repair", "chronic non-cancer pain", "shoulder ligament rupture", "lower limb bypass surgery", "sacral plexus anesthesia", "lower limb injury", "pain associated with herpes zoster", "postherpetic neuralgia", "postural tachycardia syndrome", "arteriovenous fistula surgery", "prolonged disorders of consciousness", "postoperative nausea" ] }, { "stage": "APPROVAL", "drug": "PHENAZOPYRIDINE", "drugType": "Small molecule", "indications": [ "Pain", "voiding dysfunction", "postoperative urinary retention", "middle east respiratory syndrome (mers)" ] }, { "stage": "APPROVAL", "drug": "COCAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "cocaine craving", "cocaine dependence", "cocaine abuse", "cocaine use disorder", "cardiovascular effects of cocaine" ] }, { "stage": "APPROVAL", "drug": "CENOBAMATE", "drugType": "Small molecule", "indications": [ "Seizure", "Focal impaired awareness seizure", "epilepsy", "partial-onset epilepsy", "partial onset seizures", "primary generalized tonic-clonic seizures", "focal to bilateral tonic-clonic seizures", "focal aware motor seizures", "partial-onset seizures", "generalized tonic-clonic seizures", "photosensitive epilepsy", "Focal-onset seizure", "acute frequent seizures", "status epilepticus", "focal onset epilepsy", "focal epilepsy" ] }, { "stage": "APPROVAL", "drug": "LIDOCAINE", "drugType": "Small molecule", "indications": [ "premature ejaculation", "Pruritus", "burn", "sunburn", "Back pain", "osteoarthritis", "Pain", "Ventricular arrhythmia", "digestive system disease", "Myalgia", "Muscle spasm", "disease of the tendon", "arthritic joint disease", "frozen shoulder", "urethritis", "hemorrhoid", "sprain", "neuralgia", "cardiac arrhythmia", "anaesthesia", "inflammation", "physiological sexual disorder", "infection", "neuropathic pain", "visceral pain", "postoperative recovery", "colorectal neoplasm", "spinal anesthesia", "carpal tunnel syndrome", "diabetic polyneuropathy", "postherpetic neuralgia", "overactive bladder", "procedural pain", "ileus", "post-tonsillectomy pain", "poor oral intake", "pharyngitis", "radiation skin reaction", "preeclampsia", "endoscopic sinus surgery", "sensory function impairment", "bursitis of the shoulder", "tendinitis", "ankle sprain", "forearm surgery", "arm surgery", "Laryngospasm", "fibromyalgia", "ventricular fibrillation", "ventricular tachycardia", "post-herniorrhaphy pain", "subacromial tendonitis", "supraspinatous tendonitis", "subdeltoid bursitis", "bursitis", "pain with sexual intercourse", "Dyspareunia", "Modic I discopathy", "Low back pain", "inevitable abortion", "missed abortion", "pregnancy", "incomplete abortion", "intubation", "transitory neurologic syndrome", "greater trochanteric pain syndrome", "breast cancer", "submental fullness", "cataract", "postoperative sore throat", "Cough", "Hoarse voice", "cancer pain", "peripheral neuropathic pain", "Chronic pain", "type 2 diabetes mellitus", "abortion", "feticide", "fetal asystole", "hand surgery", "delayed onset muscle soreness", "myofascial pelvic pain", "postoperative pain", "pulpitis", "large-vessel occlusion", "ischemic stroke", "chronic post-surgical pain", "intrauterine device insertion pain", "circumcision", "Headache", "Neck pain", "post-dural puncture headache", "Obesity", "migraine disorder", "acute musculoskeletal pain", "Sepsis", "septic shock", "glenohumeral arthritis", "cough reflex", "post-operative pain", "pelviabdominal cancers", "stenosing tenosynovitis", "de Quervain disease", "Digital flexor tenosynovitis", "labor pain", "colorectal cancer", "non-small cell lung carcinoma", "postthoracotomy pain", "dental restorative cases", "Anxiety", "hip fracture", "total hip arthroplasty", "acute respiratory distress syndrome", "pneumonia", "myofascial pain syndrome", "acute pain", "cardiac surgery", "acute respiratory distress", "postoperative ileus", "postoperative cognitive dysfunction", "postoperative delirium", "disability", "osteoarthritis, knee", "post-surgical pain", "cancer", "Ehlers-Danlos syndrome, hypermobility type", "post-operative oral pain", "volume deficit of the midface", "lumbar disc herniation", "mixed vaginal infections", "vulvovaginal candidiasis", "vaginitis", "bacterial vaginosis", "Hydrocele testis", "spermatocele", "postoperative complications", "central post-stroke pain", "difficult airway", "pudendal neuralgia", "local anesthesia", "postoperative pulmonary complications", "distal radius fracture", "postoperative cough", "chronic nasal congestion", "Dyspnea", "Respiratory distress", "obstructive sleep apnea syndrome", "sleep disorder", "scleroderma", "diabetic neuropathy", "topical anesthesia", "radial artery spasm", "anal hypertonia", "postoperative chronic pain", "Knee pain", "hematopoietic and lymphoid cell neoplasm", "irreversible pulpitis", "lateral epicondylitis", "complex regional pain syndrome", "dermatologic surgical procedure", "snakebite envenomation", "connective tissue neoplasm", "bone neoplasm", "Anal fissure", "cesarean section", "nasal surgery", "recovery of postoperative gastrointestinal function", "myofascial pain", "Dysmenorrhea", "painful diabetic neuropathy", "HIV-associated neuropathy", "cutaneous heat hyperalgesia", "visceral hyperalgesia", "clinical pain", "irritable bowel syndrome", "infertility disorder", "vulvar vestibulitis", "hemiplegia", "Shoulder pain", "chronic axial low back pain", "Stress urinary incontinence", "hand impairment", "Hemiparesis", "generalized vulvodynia", "interstitial cystitis", "shoulder impingement syndrome", "opioid consumption", "bowel dysfunction", "breast cancer recurrence", "post operative nausea and vomiting", "vasoocclusive sickle cell pain", "endometriosis", "tonsillectomy", "infective endocarditis", "heart valve disorder", "diabetic peripheral neuropathy", "discomfort during upper gastrointestinal endoscopy", "cocaine dependence", "adductor canal block", "complex regional pain syndrome type 2", "phantom limb pain", "scar hyperalgesia", "lumbar plexus block", "stress response of intubation", "allodynia", "anesthesia of the tympanic membrane", "renal colic", "upper extremity trauma", "Infertility", "aorto-iliac aneurysm", "postdural puncture headache", "mastodynia", "vestibulodynia", "leg ulcer", "painful trigeminal neuropathy", "trigeminal neuralgia", "blood loss", "malignant pancreatic neoplasm", "short surgery", "sickle cell crisis", "rib fracture", "myogenous face pain", "jaw muscle pain", "posttraumatic stress disorder", "anxiety symptoms", "tooth extraction", "pain following wisdom molar extractions", "chronic scrotal content pain", "malignant wounds", "peripheral neuropathy", "chronic pancreatitis", "post-extubation cough", "wound dehiscence", "surgical site swelling", "surgical site ecchymosis", "hematoma", "myofascial pain dysfunction syndrome", "mandibular permanent molars", "malignant colon neoplasm", "tourniquet-induced hypertension", "orofacial pain", "solid tumor", "delayed bowel function", "chronic migraine", "craniofacial neuralgia", "heart failure", "malignant pleural effusion", "perioperative pain", "brain neoplasm", "molar incisor hypomineralisation", "amnestic mild cognitive impairment", "molar-incisor hypomineralization", "venepuncture pain", "postoperative recovery quality", "hyperalgesia", "radial artery vasospasm", "radial artery vasodilation", "anesthesia", "provoked localized vulvodynia", "pancreatic cystic neoplasms", "pain agnosia", "lumbar radiculopathy", "herpes zoster", "pulmonary hypertension", "Morton Neuroma", "leg dominant pain", "Tinnitus", "migraine-like headache", "mandibular tooth extraction", "greater occipital neuralgia", "liver cancer", "supratentorial tumors", "lumbar disc related radicular pain", "lacertus fibrosus syndrome", "ulnar nerve compression", "stub finger", "Dupuytren Contracture", "diabetic foot", "spinal cord injury", "Plantar Fasciitis", "cortisol level post-intubation", "hemodynamic changes", "nerve damage", "pelvi-abdominal cancer", "procedure related pain", "prostate cancer", "oropharynx squamous cell carcinoma", "Inguinal hernia", "radiculitis", "temporomandibular disorders", "cesarean delivery", "postoperative nasal bleeding", "epistaxis", "cold pain", "headache disorder", "musculoskeletal pain", "chronic cancer-related pain", "vulvodynia", "perineal laceration", "perineal pain", "recovery following total abdominal hysterectomy", "vasovagal reaction", "skin cancer", "restless legs syndrome", "pain after surgery", "acute functional recovery after abdominal hysterectomy", "residual pain", "uterine curettage", "post-intubation sore throat", "postoperative swelling", "postoperative inflammation", "trochanteric bursitis", "idiopathic distal sensory neuropathy", "post-mastectomy pain syndrome", "pelvic floor tension myalgia", "masticatory myofascial pain", "Mydriasis", "Hypertension", "sensoric blockade", "motoric blockade", "refractive surgery", "methemoglobinemia", "Cyanosis", "perioperative coughing", "provoked vestibulodynia", "digital nerve block", "diabetic macular edema", "wet macular degeneration", "retinal vein occlusion", "post-herpetic neuralgia", "occipital neuralgia", "spinal block", "myocardial injury", "Arrhythmia", "loss of fatty tissue", "discomfort", "rocuronium injection pain", "Isolated systolic hypertension", "transurethral resection of prostate", "endophthalmitis", "post surgical pain", "sensory disturbances", "abnormal uterine bleeding", "cholangiocarcinoma", "intrahepatic cholangiocarcinoma", "nasal septoplasty surgery", "endometriosis pain", "fluctuance", "cellulitis", "upper extremity surgical anesthesia", "sensory and motor nerve block", "nasolabial folds", "skin erythema", "jellyfish sting", "outpatient laparoscopy", "laparoscopic gynecological surgery", "eyelid surgery", "burn injury", "patients undergoing IVRA for short operations on arm and forearm", "discomfort associated with placing a catheter in a vein", "peripheral nerve block", "hip joint pain", "phakic intraocular lens implantation", "break-through pain", "skin anesthesia", "anesthesia induction", "post-caesarean section incisional pain", "epidural anesthesia", "painful neuroma", "intolerance to endoscopy", "pre-operative sedation", "postoperative analgesia", "axillary brachial plexus block", "rhytidoplasty", "facelift surgery", "sacroiliac joint dysfunction", "plantar fasciopathy", "spastic flexion pattern of the elbow", "laryngo tracheal reflexes", "neuromuscular blockade", "second degree burn", "upper extremity surgery", "surgical anesthesia", "Pilonidal sinus", "acne scars", "traumatic scars", "cervical incompetence", "post-operative major complications", "achilles tendinopathy", "biceps tendinitis", "superficial venous insufficiency", "acute ischemic stroke", "heart failure with reduced ejection fraction", "discomfort of dental injections", "diabetes mellitus", "rotator cuff syndrome", "arteriovenous fistula", "acute kidney injury", "oesophagogastroduodenoscopy", "maxillary field block anesthesia", "abdominal wall pain", "Arthritis", "voiding efficiency impairment", "Urinary retention", "mixed urinary incontinence", "chronic lumbosacral radicular pain", "benign anorectal surgery", "pharyngolaryngeal discomfort", "propofol injection pain", "abdominal cancer pain", "rotator cuff impingement syndrome", "flexor tendon injuries", "hand and forearm pain", "hand injury", "post-laparoscopy shoulder pain", "dental procedures", "cervical radicular pain", "ocular surgery", "awake nasal fiberoptic intubation", "trauma of the upper limb", "injury", "muscle tremor", "shoulder arthroplasty", "severe airways obstruction", "cutaneous inflammation", "brachial plexus block", "major abdominal surgeries", "hemodynamic response to laryngoscopy and intubation", "popliteal block", "anterior shoulder dislocation", "voiding efficiency", "bladder emptying", "brachial plexus blockade", "vulvar biopsy pain", "postthoracotomy pain syndrome", "chronic postoperative pain", "mid-face volume deficit", "nociceptive pain", "forehead rhytides", "post-cesarean pain", "Dilatation of the cerebral artery", "extubation response", "transient neurological syndrome", "pain following circumcision", "quervain syndrome", "acute respiratory failure", "onset time of local anesthesia", "bronchial disorder", "shoulder tip pain", "burn scar", "simple lacerations", "gag reflex", "infraclavicular brachial plexus block", "achilles enthesopathy", "diabetic peripheral neuropathic pain", "post mastectomy pain syndrome", "stress", "quality of recovery", "iatrogenic pain", "foot surgery", "ankle surgery", "acute abdominal pain", "post dural puncture headache", "recovery quality after gynecological laparoscopy", "bucking", "dental anesthesia", "toothache", "laceration", "diagnostic curettage", "hysteroscopy", "neurogenic cough", "stress response to direct laryngoscopy", "Periodontal Pocket", "gynaecology surgery", "dental extraction", "upper limb surgical anaesthesia", "intractable plantar keratoma", "non-histaminergic itch", "gastric cancer", "pes anserine bursitis", "lip volume deficiency", "lumbar spine surgery", "Vomiting", "Nausea", "residual limb pain", "arteriovenous fistula failure", "chondromalacia patellae", "behavior", "acromioclavicular joint dysfunction", "bone marrow biopsy", "palatal anesthesia", "thyroidectomy", "pruritus ani", "pancreatic malignancy", "Hyperhidrosis", "female reproductive organ cancer", "piriformis syndrome", "muscle function impairment", "tussis", "left ventricular systolic dysfunction", "coronary artery disorder", "chronic pelvic pain", "postoperative delay in resumption of normal bowel function", "cervical cancer", "hemiplegic shoulder pain", "upper airway discomfort", "traumatic cervical injury", "postoperative bleeding", "mesothelioma", "bronchogenic carcinoma", "supratentorial craniotomy", "hypertrophy of labia minor", "incompetent long saphenous vein", "chronic venous disease", "varicose ulcer", "Varicose veins", "dental injection pain", "wisdom tooth extraction", "odontectomy", "post-tonsillectomy hemorrhage", "surgery of forearm, wrist, and hand", "post-thoracotomy pain syndrome", "wound infection", "hemodynamic responses to pneumoperitoneum", "abdominal eventration", "port access pain", "surgical stress response", "neuropathic foot pain", "coxarthrosis", "infectious peritonitis", "postoperative neurocognitive dysfunction", "gastroscopy", "extraction of mandibular molar", "traumatic oral ulcer", "non-sedated esophagogastroduodenoscopy", "subacromial bursitis", "Dysphagia", "cerebral palsy", "postoperative pneumonia", "atelectasis", "pharyngeal dysphagia", "gastroesophageal reflux disease", "fear", "zoster-associated pain", "stress response to laryngoscopy", "stress response to endotracheal intubation", "persistent pain post mastectomy", "hemodynamic instability", "postoperative vomiting", "postoperative nausea", "devitalized mandibular molar tooth", "perioperative neurocognitive disorders", "hemodynamic response", "nociception level index", "persistent idiopathic facial pain", "upper gastrointestinal disorders", "chronic upper back pain", "chronic mid back pain", "first trimester incomplete miscarriage", "incomplete miscarriage", "endometrial biopsy pain", "post-induction hypotension", "early intraoperative hypotension", "postpartum perineal pain", "stage 5 chronic kidney disease", "chronic idiopathic ano-perineal pain", "chronic non-cancer pain", "supraspinatus tendon injury", "sacroiliac joint pain", "recovery", "palmar hyperhidrosis", "emergency laparotomy", "endometrial thickening", "pain on injection of rocuronium", "suboptimal recovery", "heightened oral secretions", "gut function", "Insulin resistance", "increased intraocular pressure", "difficult mask ventilation", "postoperative discomfort", "cervicogenic dizziness", "atopic eczema", "discomfort during fiberoptic bronchoscopy", "complications of anesthesia and surgery", "cardiovascular responses to tracheal intubation", "pain on injection of propofol", "infected tooth", "inflamed tooth", "hypotensive disorder", "traumatic oral ulcers", "intubation condition", "hemodynamic responses to laryngoscopy", "Tachycardia", "laparoscopic cholecystectomy", "gynecologic surgery", "hepatic metastases", "hepatocellular carcinoma", "postoperative pain scores", "Hoffa's fat pad impingement", "arteriovenous fistula surgery", "emergence agitation", "hemorrhoidal prolapse", "perioperative nociceptive control", "ambulatory hand surgery", "ambulatory foot surgery", "leg telangiectasias", "Popliteal synovial cyst", "neuroma-related pain", "postoperative emergence agitation", "postoperative trismus", "lumbar spinal surgery", "postoperative cognitive delirium", "pulmonary injury", "chronic neck pain", "orbital akinesia", "stress of endotracheal intubation", "medication overuse headache" ] }, { "stage": "APPROVAL", "drug": "TOPIRAMATE", "drugType": "Small molecule", "indications": [ "epilepsy", "migraine disorder", "Lennox-Gastaut syndrome", "Seizure", "alcohol dependence", "bipolar disorder", "manic episode", "mixed episode", "bipolar I disorder", "partial-onset seizures", "obsessive-compulsive disorder", "obsessive-compulsive problems", "Motor tics", "attention deficit-hyperactivity disorder", "Tourette syndrome", "type 2 diabetes mellitus", "obesity disorder", "inherited lipid metabolism disorder", "generalized tonic-clonic seizure", "essential tremor", "essential hypertension", "primary generalized tonic-clonic seizures", "Generalized-onset seizure", "partial onset seizures", "partial onset epilepsy", "secondarily generalized seizures", "acute manic episode", "Obesity", "gambling behaviour", "cocaine dependence", "tobacco addiction", "nicotine dependence", "binge eating disorder", "Borderline personality disorder", "post-traumatic stress disorder", "Overweight", "polycystic ovary syndrome", "impulsivity", "Polyphagia", "Self-injurious behavior", "Prader-Willi syndrome", "alcohol abuse", "diabetes mellitus", "Uric acid nephrolithiasis", "nephrolithiasis, calcium oxalate", "Calcium oxalate nephrolithiasis", "non-convulsive status epilepticus", "eating disorder", "Addictive alcohol use", "posttraumatic stress disorder", "Epileptic spasm", "orofacial neuropathic pain syndromes", "trigeminal neuralgia", "lumbar radiculopathy", "Sciatica", "smoking cessation", "childhood absence epilepsy", "multiple sclerosis", "cocaine craving", "Abdominal obesity", "diabetic peripheral polyneuropathy", "focal epilepsy", "Focal-onset seizure", "Parkinson disease", "Dyskinesia", "methamphetamine dependence", "problem gambling", "pathological gambling", "cocaine abstinence", "Cannabis use", "brain ischemia", "vascular dysfunction", "heavy drinking", "body mass index reduction", "compulsive buying", "cryptogenic sensory peripheral neuropathy", "metabolic syndrome", "weight regain", "morbid obesity", "ulcerative colitis", "sudden sensorineural hearing loss", "human immunodeficiency virus 1 infection", "human immunodeficiency virus infection", "migraine prophylaxis", "schizoaffective disorder", "Pain", "Rett syndrome", "generalized social phobia", "alcohol withdrawal", "migraine with aura", "generalized tonic-clonic seizures", "cannabis use disorder", "bipolar mania", "medication overuse headache", "problem drinking", "migraine-associated dizziness", "bulimia nervosa", "post-traumatic headache", "chronic migraine", "probable vestibular migraine", "Neuhauser definite vestibular migraine", "non-Neuhauser vestibular migraine", "vestibular migraine", "compulsive sexual behavior", "schizophrenia", "migraine without aura", "obesity-associated comorbidities" ] }, { "stage": "APPROVAL", "drug": "PROCAINE", "drugType": "Small molecule", "indications": [ "hemorrhoid", "anaesthesia", "osteoarthritis", "radiation-induced oral mucositis", "acute kidney injury", "chronic non-cancer pain" ] }, { "stage": "APPROVAL", "drug": "PROPOXYCAINE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "APPROVAL", "drug": "PRIMIDONE", "drugType": "Small molecule", "indications": [ "epilepsy", "clopidogrel resistance", "essential tremor" ] }, { "stage": "APPROVAL", "drug": "CHLOROPROCAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "distal upper limb surgery", "unplanned caesarean section", "postoperative pain", "postoperative nausea", "cataract", "ocular surface anesthesia", "hemorrhoidectomy", "knee surgery", "Inguinal hernia", "flatfoot", "post-partum tubal ligation", "labor pain", "cesarean delivery", "surgical pain", "spinal anesthesia", "epidural anesthesia", "ambulatory minor foot surgery", "acute kidney injury", "Umbilical hernia", "knee arthroscopy", "cervical cerclage", "inguinal herniorrhaphy", "ambulatory knee arthroscopy", "motor block", "knee arthroplasty", "hip arthroplasty", "cesarean section", "manipulation under anesthesia" ] }, { "stage": "APPROVAL", "drug": "ESLICARBAZEPINE ACETATE", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "partial onset seizures", "focal epilepsy", "Focal-onset seizure", "simple partial seizures", "Focal impaired awareness seizure", "post-herpetic neuralgia", "diabetic neuropathic pain", "partial-onset seizures", "diabetic neuropathy", "fibromyalgia", "acute manic episode", "acute mania", "bipolar I disorder", "partial-onset epilepsy" ] }, { "stage": "APPROVAL", "drug": "ORPHENADRINE", "drugType": "Small molecule", "indications": [ "Parkinson disease", "muscle cramp", "Low back pain", "osteoarthritis", "Pain", "postoperative ileus", "postoperative pain", "musculoskeletal system disorder", "Neck pain" ] }, { "stage": "APPROVAL", "drug": "LACOSAMIDE", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "convulsion", "focal epilepsy", "diabetic neuropathy", "secondarily generalized tonic-clonic seizures", "Focal-onset seizure", "neuropathic pain", "partial-onset seizures", "distal diabetic neuropathy", "breakthrough seizures", "generalized tonic-clonic seizures", "primary erythermalgia", "partial onset seizures", "epilepsy with partial-onset seizures", "primary generalized tonic-clonic seizures", "idiopathic generalized epilepsy", "generalized onset tonic-clonic seizures", "Bilateral tonic-clonic seizure", "status epilepticus", "non-convulsive status epilepticus", "Sciatica", "migraine disorder", "bipolar disorder", "major depressive episode", "postherpetic neuralgia", "fibromyalgia", "osteoarthritis, knee", "peripheral diabetic neuropathy", "primary generalized epilepsy", "nonconvulsive seizures", "epilepsy syndromes associated with generalized seizures", "peripheral neuropathic pain", "alcohol dependence", "amyotrophic lateral sclerosis", "opioid-induced hyperalgesia", "chronic pancreatitis", "partial-onset epilepsy", "partial onset epilepsy", "cognitive function impairment", "depressive disorder", "Anxiety", "autoimmune-associated epilepsy", "acute symptomatic seizure secondary to autoimmune encephalitis", "acute brain injury", "electrographic status epilepticus", "Coma", "trigeminal neuralgia", "Pain", "Convulsive status epilepticus", "post herpetic neuralgia" ] }, { "stage": "APPROVAL", "drug": "PROCAINAMIDE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Ventricular arrhythmia", "cardiac arrhythmia" ] }, { "stage": "APPROVAL", "drug": "PHENYTOIN SODIUM", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "cancer" ] }, { "stage": "APPROVAL", "drug": "DRONEDARONE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "angina pectoris", "atrial fibrillation", "atrial flutter", "left ventricular dysfunction", "congestive heart failure", "Paroxysmal atrial fibrillation", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "ENCAINIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "complex ventricular arrhythmia", "heart arrhythmia" ] }, { "stage": "APPROVAL", "drug": "MEPIVACAINE", "drugType": "Small molecule", "indications": [ "pain agnosia", "severe pain", "Pain", "motor deficit", "visual scotoma", "Cerebral visual impairment", "Aphasia", "compartment syndrome", "knee arthroscopy surgery", "distal upper extremity surgery", "anesthesia", "shoulder arthroscopy", "irreversible pulpitis", "knee arthroscopy", "ambulatory minor foot surgery", "gingival recession", "Miller class I gingival recession", "third molar extraction", "acute kidney injury", "upper limb pain", "formarm or hand surgery", "ischemic hypertension", "pain during maxillary teeth extraction", "tooth decay", "hip arthroplasty", "postoperative pain", "sensory blockade", "total hip arthroplasty", "total knee arthroplasty", "carpal tunnel syndrome" ] }, { "stage": "APPROVAL", "drug": "TOCAINIDE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "Ventricular arrhythmia" ] }, { "stage": "APPROVAL", "drug": "PRILOCAINE", "drugType": "Small molecule", "indications": [ "Pain", "anaesthesia", "physiological sexual disorder", "sensory function impairment", "spinal anesthesia", "cesarean section", "circumcision", "hemodynamics", "Hydrocele testis", "spermatocele", "arthroscopy on the knee", "premature ejaculation", "postherpetic neuralgia", "scheduled cesarean delivery", "motor block", "amnestic mild cognitive impairment", "venepuncture pain", "knee surgery", "below knee orthopedic surgery", "methemoglobinemia", "Cyanosis", "distal sciatic nerve block", "nerve damage", "anal surgery", "regional anesthesia", "carotid artery surgery", "knee arthroscopy", "acute kidney injury", "Inguinal hernia", "Umbilical hernia", "radial artery spasm", "forehead rhytides", "maxillary teeth extraction", "stress", "abnormal uterine bleeding", "postoperative pain", "upper extremity surgery", "cystoscopy procedures", "cardiac dysfunction", "peripheral vascular disease", "subacromial impingement syndrome", "rotator cuff lesion", "Shoulder pain", "hypotensive disorder", "fear", "arteriovenous fistula", "perianal surgery", "osteoarthritis, knee", "total knee replacement", "postoperative shivering" ] }, { "stage": "APPROVAL", "drug": "ARTICAINE", "drugType": "Small molecule", "indications": [ "anaesthesia", "spinal anesthesia", "lower limb surgery", "pulpitis", "local anesthesia", "Pain", "ocular anesthesia", "soft tissue local anesthesia effect", "irreversible pulpitis", "pulpal anesthesia", "tooth extraction", "molar incisor hypomineralisation", "molar-incisor hypomineralization", "mandibular tooth extraction", "upper limb procedure", "nerve damage", "mandibular molar extraction", "acute pain", "upper gastrointestinal endoscopy", "extraction of lower third molars", "acute kidney injury", "maxillary teeth extraction", "dental procedures", "lower wisdom teeth extraction", "lower third molar extraction", "pain during maxillary teeth extraction", "tooth decay", "behavior", "wisdom tooth extraction", "odontectomy", "high frenal attachment", "extraction of mandibular molar", "postoperative pain", "ambulatory orthopedic surgery", "dental phobia" ] }, { "stage": "APPROVAL", "drug": "RILUZOLE", "drugType": "Small molecule", "indications": [ "amyotrophic lateral sclerosis", "progressive supranuclear palsy", "multiple system atrophy", "Huntington disease", "Myelopathy", "spinocerebellar ataxia type 2", "cerebellar ataxia", "spinal muscular atrophy", "spinal cord injury", "social phobia", "spinocerebellar ataxia 7", "Parkinson disease", "major depressive disorder", "depressive disorder", "bipolar disorder", "cerebellar syndrome", "obsessive-compulsive disorder", "multiple sclerosis", "Anxiety", "melanoma", "Irritability", "Hyperactivity", "autism spectrum disorder", "Alzheimer disease", "frontotemporal dementia", "Spasticity", "atrial fibrillation", "Tachycardia", "cancer-related cognitive impairment", "post-traumatic stress disorder", "breast cancer", "brain metastasis", "solid tumors", "colorectal cancer", "schizophrenia", "spastic hyper-reflexia" ] }, { "stage": "APPROVAL", "drug": "MEPHENYTOIN", "drugType": "Small molecule", "indications": [ "epilepsy" ] }, { "stage": "APPROVAL", "drug": "ZONISAMIDE", "drugType": "Small molecule", "indications": [ "epilepsy", "Seizure", "Parkinsonism", "Parkinson disease", "focal epilepsy", "binge eating disorder", "Obesity", "simple partial seizures", "partial seizures with secondary generalization", "Focal impaired awareness seizure", "Focal-onset seizure", "partial onset seizures", "primary generalised tonic-clonic seizures", "early-infantile DEE", "myoclonus-dystonia syndrome", "alcohol dependence", "alcohol abuse", "cigarette smoking", "nicotine dependence", "migraine disorder", "Tremor", "essential tremor", "obesity disorder", "heavy drinking", "bipolar disorder", "obstructive sleep apnea syndrome", "post-traumatic stress disorder", "hearing loss disorder", "cocaine dependence", "focal epileptic seizures", "partial onset epileptic crisis", "levodopa-induced dyskinesia", "motor fluctuations", "nonmotor symptoms", "Cognitive impairment", "partial-onset seizures" ] }, { "stage": "APPROVAL", "drug": "ETIDOCAINE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "APPROVAL", "drug": "MEXILETINE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "ventricular tachycardia", "ventricular fibrillation", "Sudden death", "diabetic neuropathy", "non-dystrophic myotonia", "myotonic disorders", "myotonic dystrophy type 1", "myotonic dystrophy type 2", "sodium channel myotonia", "paramyotonia congenita of Von Eulenburg", "Thomsen and Becker disease", "congenital myotonia", "dystonic disorder", "stump pain", "postamputation pain", "phantom pain", "nondystrophic myotonia", "amyotrophic lateral sclerosis", "Muscle stiffness", "Charcot-Marie-Tooth disease", "muscle cramp", "irritable bowel syndrome", "cryptogenic sensory polyneuropathy", "sudden cardiac arrest", "Myotonia" ] }, { "stage": "APPROVAL", "drug": "LIDOCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Pain", "Back pain", "prostate carcinoma", "sensory function impairment", "middle ear effusion", "copper intrauterine device insertion", "acute pain", "perineal laceration", "migraine disorder", "Hydrocele testis", "spermatocele", "Cough", "recovery of postoperative gastrointestinal function", "postoperative pain", "postoperative sore throat", "hemiplegia", "Shoulder pain", "interstitial cystitis", "hemorrhoid", "tympanostomy tube placement", "outpatient hysteroscopy", "mandibular permanent molars", "irreversible pulpitis", "subarachnoid hemorrhage", "Headache", "venepuncture pain", "actinic keratosis", "malignant hypertension", "internal hemorrhoids", "cardiac arrest", "exocrine pancreatic carcinoma", "lumbar stenosis", "nervous system disorder", "rotator cuff disease", "ureteral stent symptoms", "break-through pain", "pre-operative sedation", "second degree burn", "impacted lower third molars", "carpal tunnel syndrome", "primary maxillary second molars", "cognitive dysfunction", "vulvar biopsy pain", "wound pain", "limited spine mobility", "axial spondyloarthritis", "cataract", "frozen shoulder", "supratentorial craniotomy", "ear tube placement procedure", "maxillary tooth extraction", "Dysphagia", "Cognitive impairment", "cerebral small vessel disease", "pharyngeal dysphagia", "Stroke", "obstructive sleep apnea syndrome", "insomnia", "autism", "Parkinson disease", "traumatic brain injury", "gastroesophageal reflux disease", "cerebral palsy", "bulbar palsy", "ischemic stroke", "temporomandibular joint dysfunction", "Parkinson's syndrome", "Drooling", "Obesity", "postpartum perineal pain", "post-operative pain", "discomfort during fiberoptic bronchoscopy", "hemodynamic responses to laryngoscopy", "Tachycardia", "Hypertension", "radicular pain", "lumbar disc herniation" ] }, { "stage": "APPROVAL", "drug": "COCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "cocaine dependence", "cocaine use disorder" ] }, { "stage": "APPROVAL", "drug": "HEXYLCAINE", "drugType": "Small molecule", "indications": [ "anaesthesia" ] }, { "stage": "APPROVAL", "drug": "QUINIDINE GLUCONATE", "drugType": "Small molecule", "indications": [ "Ventricular arrhythmia", "malaria" ] }, { "stage": "APPROVAL", "drug": "QUINIDINE", "drugType": "Small molecule", "indications": [ "cardiac arrhythmia", "ventricular fibrillation", "Sudden death", "ventricular tachycardia", "atrial fibrillation", "pseudobulbar affect", "amyotrophic lateral sclerosis", "peripheral neuropathic pain", "diabetic peripheral neuropathy", "Irritability", "diabetic neuropathy", "neuropathic pain", "multiple sclerosis", "Agitation", "Alzheimer disease", "levodopa-induced dyskinesia", "Parkinson disease", "major depressive disorder", "paroxysmal familial ventricular fibrillation", "multifocal ectopic Purkinje-related premature contractions", "Andersen-Tawil syndrome", "traumatic brain injury" ] }, { "stage": "APPROVAL", "drug": "TETRACAINE", "drugType": "Small molecule", "indications": [ "Pain", "hemorrhoid", "Pruritus", "spinal anesthesia", "pulpal anesthesia", "corneal abrasion", "cataract", "postherpetic neuralgia", "carpal tunnel syndrome", "shoulder impingement syndrome", "local anesthesia", "myopic astigmatism", "myopia", "osteoarthritis", "peripheral neuropathic pain", "toothache", "post-intubation sore throat", "anesthesia", "refractive surgery", "phakic intraocular lens surgery", "phakic intraocular lens implantation", "acute kidney injury", "skin reaction", "need root canal treatment", "discomfort of intravenous insertion", "simple lacerations", "laceration" ] }, { "stage": "APPROVAL", "drug": "MEXILETINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Ventricular arrhythmia", "myotonic disorders", "Kennedy disease", "bulbospinal muscular atrophy" ] }, { "stage": "APPROVAL", "drug": "ORPHENADRINE CITRATE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "APPROVAL", "drug": "LAMOTRIGINE", "drugType": "Small molecule", "indications": [ "epilepsy", "bipolar disorder", "major depressive disorder", "Seizure", "bipolar I disorder", "Bilateral tonic-clonic seizure", "Lennox-Gastaut syndrome", "focal epilepsy", "partial onset seizures", "mania", "hypomania", "depressive disorder", "peripheral neuropathy", "schizophrenia", "bipolar II disorder", "childhood absence epilepsy", "primary generalized tonic-clonic seizures", "Focal-onset seizure", "eating disorder", "obesity disorder", "simple partial seizures", "partial seizures with secondary generalization", "Focal impaired awareness seizure", "alcohol dependence", "post-traumatic stress disorder", "mood disorder", "Typical absence seizure", "localization related epilepsy", "Myotonia", "psychologic side-effect", "non-dystrophic myotonia", "post-herpetic neuralgia", "trigeminal neuralgia", "neurofibromatosis type 1", "ketamine dependence", "opiate withdrawal", "unipolar mood disorders", "cocaine dependence", "bipolar mood disorder", "mixed mania", "disability", "multiple sclerosis", "pathologic skin picking", "neurotic excoriation", "Meniere disease", "Cognitive impairment", "alcohol use", "Vertigo", "Generalized non-motor (absence) seizure", "bipolar mood disorders", "memory loss", "mood changes", "alcohol withdrawal", "neuropathic facial pain", "premenstrual dysphoric disorder", "unipolar major depressive disorder", "Generalized-onset seizure", "neuralgia", "migraine disorder", "bipolar II depression", "acute postoperative pain", "post-mastectomy pain syndrome", "mood instability" ] }, { "stage": "APPROVAL", "drug": "ESLICARBAZEPINE", "drugType": "Small molecule", "indications": [ "epilepsy" ] }, { "stage": "APPROVAL", "drug": "FOSPHENYTOIN SODIUM", "drugType": "Small molecule", "indications": [] }, { "stage": "APPROVAL", "drug": "CARBAMAZEPINE", "drugType": "Small molecule", "indications": [ "Seizure", "epilepsy", "trigeminal neuralgia", "glossopharyngeal nerve disorder", "focal epilepsy", "bipolar I disorder", "bipolar disorder", "type 1 diabetes mellitus", "gastric adenocarcinoma", "partial onset seizures", "generalized tonic-clonic seizures", "partial-onset seizures", "cocaine dependence", "cocaine craving", "infantile spasms", "human immunodeficiency virus drug resistance", "human immunodeficiency virus infection", "liver disorder", "facial pain", "schizophrenia", "bronchial asthma", "generalised tonic-clonic seizures", "Focal-onset seizure", "premenstrual dysphoric disorder", "Irritability", "aggressive behavior", "carpal tunnel syndrome", "inherited erythromelalgia", "alcohol withdrawal", "drug-resistant epilepsy", "substance use disorder" ] }, { "stage": "APPROVAL", "drug": "DYCLONINE", "drugType": "Small molecule", "indications": [ "Pain" ] }, { "stage": "PHASE_3", "drug": "MEPIVACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "Pain", "perineal laceration", "irreversible pulpitis", "maxillary teeth extraction", "diabetes mellitus", "tooth extraction" ] }, { "stage": "PHASE_3", "drug": "RALFINAMIDE", "drugType": "Small molecule", "indications": [ "neuropathic pain", "post-traumatic lumbar radiculopathy", "neuropathic low back pain", "compression radiculopathy", "post-surgical lumbar radiculopathy" ] }, { "stage": "PHASE_3", "drug": "VIXOTRIGINE", "drugType": "Small molecule", "indications": [ "trigeminal neuralgia", "bipolar disorder", "lumbosacral radiculopathy", "neuropathic pain", "radiculopathy", "erythromelalgia", "diabetes mellitus", "neuropathy, small fiber", "diabetic polyneuropathy" ] }, { "stage": "PHASE_3", "drug": "PROCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "oral aphthous ulcers", "Oral ulcer", "human immunodeficiency virus infection", "AIDS" ] }, { "stage": "PHASE_3", "drug": "EVENAMIDE", "drugType": "Small molecule", "indications": [ "schizophrenia" ] }, { "stage": "PHASE_3", "drug": "PROPARACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "ocular anesthesia", "Vitreous floaters" ] }, { "stage": "PHASE_3", "drug": "BENOXINATE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "ocular surface anesthesia", "postoperative pain" ] }, { "stage": "PHASE_3", "drug": "TETRACAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "pulpal anesthesia", "local anesthesia", "corneal abrasion", "maxillary teeth", "acute pain" ] }, { "stage": "PHASE_2", "drug": "PF-05089771", "drugType": "Small molecule", "indications": [ "Chronic pain", "toothache", "Pain", "erythromelalgia", "diabetic peripheral neuropathy", "cold pain" ] }, { "stage": "PHASE_2", "drug": "MORICIZINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "complex ventricular arrhythmia" ] }, { "stage": "PHASE_2", "drug": "NERISPIRDINE", "drugType": "Small molecule", "indications": [ "multiple sclerosis", "spinal cord injury", "visual function impairment" ] }, { "stage": "PHASE_1", "drug": "AZD3161", "drugType": "Unknown", "indications": [ "peripheral neuropathy", "mechanical pain sensitivity", "axon reflex flare" ] }, { "stage": "PHASE_1", "drug": "RG7893", "drugType": "Unknown", "indications": [ "Pain" ] }, { "stage": "PHASE_1", "drug": "XEN403", "drugType": "Unknown", "indications": [ "Pain" ] }, { "stage": "PHASE_1", "drug": "DSP-2230", "drugType": "Small molecule", "indications": [ "neuropathic pain" ] }, { "stage": "PHASE_1", "drug": "RG6029", "drugType": "Unknown", "indications": [ "Chronic pain" ] }, { "stage": "UNKNOWN", "drug": "ENCAINIDE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [] }, { "stage": "UNKNOWN", "drug": "DYCLONINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "colonoscopy" ] }, { "stage": "UNKNOWN", "drug": "PRILOCAINE HYDROCHLORIDE", "drugType": "Small molecule", "indications": [ "spinal anesthesia", "frozen shoulder" ] }, { "stage": "IND", "drug": "NKTR-171", "drugType": "Unknown", "indications": [ "neuropathic pain" ] } ] }, "dgidb": { "count": 91, "drugs": [ { "drug": "TETRODOTOXIN", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "XEN403", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "IRAMPANEL", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "XEN907", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "N-ME-AMINOPYRIMIDINONE 9", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "PF\u201006526290", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "QUINIDINE POLYGALACTURONATE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "VIXOTRIGINE", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology", "TTD" ] }, { "drug": "LIDOCAINE", "approved": true, "types": [ "blocker" ], "sources": [ "TEND", "TdgClinicalTrial", "ChEMBL" ] }, { "drug": "FUNAPIDE", "approved": false, "types": [ "inhibitor" ], "sources": [ "TdgClinicalTrial", "GuideToPharmacology", "TTD" ] }, { "drug": "CD2+", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "PHENYTOIN SODIUM", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "HEXYLCAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ESLICARBAZEPINE ACETATE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "DICHLOROBENZYL ALCOHOL", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PROPOFOL", "approved": true, "types": [], "sources": [ "PharmGKB" ] }, { "drug": "OXCARBAZEPINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ORPHENADRINE CITRATE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "NERISPIRDINE", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "CHLOROPROCAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "MEPHENYTOIN", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ANP-230", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "ABBV-318", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "MEPIVACAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "AMOROLFINE", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "RUFINAMIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "EVENAMIDE", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "SAFINAMIDE", "approved": true, "types": [], "sources": [ "TdgClinicalTrial" ] }, { "drug": "NKTR-171", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "RG6029", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "RALFINAMIDE", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ZONISAMIDE", "approved": true, "types": [ "blocker" ], "sources": [ "TdgClinicalTrial", "ChEMBL" ] }, { "drug": "BIIB-095", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "RG7893", "approved": false, "types": [ "blocker" ], "sources": [ "TTD", "ChEMBL" ] }, { "drug": "ARTICAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "DISOPYRAMIDE PHOSPHATE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PROPOXYCAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "TOCAINIDE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "TETRACAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "MERETHOXYLLINE PROCAINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PHENAZOPYRIDINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "AM-6120", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "MORICIZINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PYRROLOPYRIMIDINE 48 [PMID: 22318156]", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "DRONEDARONE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "CANNABINOL", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "PRIMIDONE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "DYCLONINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "DS-1971A", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "PF-05241328", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "PRILOCAINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PF-05089771", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "CENOBAMATE", "approved": true, "types": [ "inhibitor" ], "sources": [ "ChEMBL" ] }, { "drug": "ORPHENADRINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "CANNABIGEROL", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "BATRACHOTOXIN", "approved": false, "types": [ "activator" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "INDECAINIDE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PROCAINAMIDE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "TETRACAINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "MEXILETINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PF-04856264", "approved": false, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "PF-05186462", "approved": false, "types": [], "sources": [ "TTD" ] }, { "drug": "TOPIRAMATE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PROCAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ETHOTOIN", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "COCAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "CANNABIDIOL", "approved": true, "types": [ "blocker" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "BENOXINATE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "RANOLAZINE", "approved": true, "types": [], "sources": [ "TdgClinicalTrial" ] }, { "drug": "QUINIDINE GLUCONATE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "RILUZOLE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "DSP-2230", "approved": false, "types": [ "blocker" ], "sources": [ "TTD", "ChEMBL" ] }, { "drug": "PHENACEMIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PROPARACAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "GNE-131", "approved": false, "types": [ "inhibitor" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "FOSPHENYTOIN SODIUM", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PRILOCAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "QUINIDINE SULFATE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "CARBAMAZEPINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "PROPAFENONE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "AZD3161", "approved": false, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "VERATRIDINE", "approved": false, "types": [ "activator" ], "sources": [ "GuideToPharmacology" ] }, { "drug": "ROPIVACAINE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ESLICARBAZEPINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "ENCAINIDE HYDROCHLORIDE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "LACOSAMIDE", "approved": true, "types": [ "blocker", "blocker" ], "sources": [ "GuideToPharmacology", "ChEMBL" ] }, { "drug": "LAMOTRIGINE", "approved": true, "types": [ "blocker" ], "sources": [ "ChEMBL" ] }, { "drug": "GNE-616", "approved": false, 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