gene_symbol gene_name compartments chromosome gtex_z_hand gtex_z_lung gtex_z_mean pcawg_z_hand pcawg_z_lung tpm_hand tpm_lung shortlist_tier screen_flag ot_agents ot_oncology ot_indications dgidb_n_drugs ctgov_n_trials GPX6 glutathione peroxidase 6 6p22.1 25.82 26.88 26.35 26.3 27.38 4.567 4.972 none 0 0 RGPD5 RANBP2 like and GRIP domain containing 5 2q13 34.32 10.53 22.43 12.08 3.18 0.905 0.232 none 0 0 IFNL2 interferon lambda 2 19q13.2 29.89 13.32 21.61 9.9 4.25 20.9 3.03 none 0 3 TRIM43 tripartite motif containing 43 2q11.1 14.8 26.79 20.8 2.48 4.65 1.133 2.905 none 0 0 TRIM43B tripartite motif containing 43B 2q11.1 12.65 28.91 20.78 2.16 5.14 0.542 1.666 none 0 0 INSL4 insulin like 4 Vesicles 9p24.1 3.88 37.44 20.66 0.1 2.76 0.141 2.235 none 0 1 HNRNPCL4 heterogeneous nuclear ribonucleoprotein C like 4 Nucleus 1p36.21 11.4 25.13 18.27 1.09 2.68 0.2 0.481 none 0 0 BOLA2B bolA family member 2B 16p11.2 9.62 22.69 16.16 -0.61 1.02 0.764 2.594 none 0 0 IFNL1 interferon lambda 1 19q13.2 19.3 11.71 15.51 4.25 2.4 5.236 2.083 review 1 8 PIWIL3 piwi like RNA-mediated gene silencing 3 Cytosol 22q11.23 22.48 7.06 14.77 12.05 3.65 9.807 1.141 none 0 0 H2BC12L H2B clustered histone 12 like Nucleus;Cytosol 21q22.3 19.92 6.73 13.33 2.21 -0.06 3.829 0.743 none 0 0 SCN10A sodium voltage-gated channel alpha subunit 10 Cytoskeleton 3p22.2 20.33 5.92 13.12 35.78 10.53 4.029 0.624 clinical TETRACAINE; DRONEDARONE HYDROCHLORIDE; PROCAINE no Pain; cardiac arrhythmia; epilepsy 89 2 HNRNPCL2 heterogeneous nuclear ribonucleoprotein C like 2 Nucleus 1p36.21 5.54 20.65 13.09 0.297 1.466 none 0 0 TRIM49B tripartite motif containing 49B 11p11.12 5.39 20.67 13.03 1.39 5.64 0.318 1.82 none 0 0 PPIAL4D peptidylprolyl isomerase A like 4D 1q21.1 5.28 20.72 13.0 0.814 6.759 none 0 0 PTCHD4 patched domain containing 4 Plasma membrane;Cytosol 6p12.3 10.79 8.72 9.75 2.82 2.18 11.065 6.766 none 0 0 GIP gastric inhibitory polypeptide 17q21.32 10.16 8.95 9.55 3.72 3.24 2.978 2.385 none 0 825 TRIM49 tripartite motif containing 49 11q14.3 4.09 14.66 9.38 1.26 4.75 0.191 0.839 none 0 0 KCNH7 potassium voltage-gated channel subfamily H member 7 2q24.2 14.64 3.87 9.26 18.73 5.06 69.399 2.389 clinical DALFAMPRIDINE; AMIFAMPRIDINE; TEDISAMIL yes multiple sclerosis; myasthenia gravis; cardiac arrhythmia 6 0 LCN1 lipocalin 1 9q34.3 9.0 8.63 8.82 9.2 8.82 35.389 30.573 none 0 2 TRIM49C tripartite motif containing 49C 11q14.3 6.25 10.72 8.48 2.0 3.5 0.223 0.407 none 0 0 SLC6A3 solute carrier family 6 member 3 Vesicles 5p15.33 10.31 6.48 8.39 3.66 2.23 135.348 22.848 biology clinical LISDEXAMFETAMINE DIMESYLATE; NOMIFENSINE; BUPROPION no attention deficit-hyperactivity disorder; major depressive disorder; obesity disorder 72 138 COL10A1 collagen type X alpha 1 chain Endoplasmic reticulum 6q22.1 8.57 7.05 7.81 1.46 1.06 55.558 28.014 biology none 0 0 ROS1 ROS proto-oncogene 1, receptor tyrosine kinase Vesicles 6q22.1 8.48 6.84 7.66 6.77 5.43 178.332 67.297 pathway clinical CRIZOTINIB; ENTRECTINIB; REPOTRECTINIB yes non-small cell lung carcinoma 49 267 TEX15 testis expressed 15, meiosis and synapsis associated Nucleus;Cytosol 8p12 9.5 5.74 7.62 10.37 6.24 125.321 18.869 none 0 0 CRYBA4 crystallin beta A4 22q12.1 7.8 6.7 7.25 4.19 3.57 7.651 5.508 none 0 0 PAEP progestagen associated endometrial protein 9q34.3 9.34 4.9 7.12 2.15 0.9 19.819 4.166 review 3 16 DCC DCC netrin 1 receptor Golgi apparatus;Cytoskeleton 18q21.2 9.47 4.48 6.98 10.67 5.18 74.166 7.726 none 0 333 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 Cytosol 17q21.32 8.94 4.85 6.89 3.98 1.94 92.071 11.514 none 0 0 MC5R melanocortin 5 receptor Plasma membrane 18p11.21 7.4 6.32 6.86 5.15 4.39 3.392 2.576 review 12 2 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 Plasma membrane;Nucleus 7p22.3 9.0 4.72 6.86 5.65 2.86 335.357 31.037 biology none 0 0 SCN9A sodium voltage-gated channel alpha subunit 9 Plasma membrane;Cytoskeleton 2q24.3 8.44 5.1 6.77 7.3 4.46 536.007 59.51 biology clinical PROPAFENONE HYDROCHLORIDE; MORICIZINE; FOSPHENYTOIN no Pain; cardiac arrhythmia; epilepsy 91 11 ANP32D acidic nuclear phosphoprotein 32 family member D Nucleus;Cytoskeleton 12q13.11 9.55 3.86 6.71 8.29 3.4 2.068 0.652 none 0 0 ATP5MGL ATP synthase membrane subunit g like Mitochondria 22q13.2 9.13 4.19 6.66 2.89 1.02 1.549 0.601 none 0 0 PTPRQ protein tyrosine phosphatase receptor type Q Cytosol 12q21.31 8.62 4.65 6.63 12.4 6.95 217.42 21.196 none 0 0 SETSIP SET like protein Nucleus;Vesicles 1p22.1 4.93 8.26 6.59 1.79 3.53 1.487 3.142 none 0 0 FREM2 FRAS1 related extracellular matrix 2 Cytosol 13q13.3 7.85 4.98 6.42 4.11 2.46 109.006 21.897 none 0 0 AQP2 aquaporin 2 12q13.12 6.48 6.33 6.41 8.29 8.11 27.548 25.592 review 1 47 KERA keratocan 12q21.33 9.01 3.59 6.3 5.02 1.9 10.489 1.805 none 0 11 CYP3A7 cytochrome P450 family 3 subfamily A member 7 Cytosol 7q22.1 6.1 6.1 6.1 2.32 2.32 28.78 28.814 clinical COBICISTAT; RITONAVIR yes HIV-1 infection; HIV infectious disease 14 4 CST2 cystatin SA 20p11.21 4.88 6.9 5.89 1.15 1.9 7.652 18.546 none 0 3 PRSS56 serine protease 56 2q37.1 5.72 6.05 5.88 6.53 6.9 17.37 20.505 none 0 0 SLC17A3 solute carrier family 17 member 3 6p22.2 7.08 4.53 5.8 1.54 0.86 20.318 6.403 review 1 0 CTXN3 cortexin 3 5q23.2 4.55 6.99 5.77 7.18 10.84 29.146 159.784 none 0 0 PNOC prepronociceptin Vesicles 8p21.1 5.8 5.66 5.73 2.77 2.69 188.688 168.797 biology none 0 44 H4C15 H4 clustered histone 15 1q21.2 6.35 4.9 5.62 0.22 0.171 none 0 0 PRAMEF15 PRAME family member 15 1p36.21 3.16 8.07 5.62 55.03 136.63 0.074 0.193 none 0 0 TAC3 tachykinin precursor 3 Vesicles 12q13.3 4.84 6.17 5.5 8.09 10.15 160.996 547.166 biology review 1 3 EYA1 EYA transcriptional coactivator and phosphatase 1 Nucleus;Vesicles 8q13.3 6.81 4.17 5.49 5.11 3.11 120.923 21.543 biology review 1 0 LRRC15 leucine rich repeat containing 15 Plasma membrane;Vesicles 3q29 4.44 6.47 5.46 1.83 2.89 36.622 158.691 surface review 3 7 OR11H12 olfactory receptor family 11 subfamily H member 12 14q11.2 6.77 3.99 5.38 2.92 1.66 0.14 0.082 none 0 0 EIF3CL eukaryotic translation initiation factor 3 subunit C like Cytosol 16p12.1 5.78 4.93 5.36 2.42 1.94 2.748 2.216 none 0 0 TAFA3 TAFA chemokine like family member 3 1p13.2 5.51 5.17 5.34 4.53 4.24 24.237 20.064 none 0 0 SLC17A1 solute carrier family 17 member 1 6p22.2 7.24 3.1 5.17 2.08 0.66 33.314 3.846 none 0 0 STRA6 signaling receptor and transporter of retinol STRA6 15q24.1 6.91 3.41 5.16 3.28 1.26 103.363 10.912 none 0 4 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 Golgi apparatus;Vesicles 10q22.1 7.27 3.02 5.14 5.67 2.1 337.591 16.616 biology none 0 0 SLX1B structure-specific endonuclease subunit SLX1B Nucleus 16p11.2 4.49 5.67 5.08 4.65 5.76 0.816 1.056 none 0 0 SLC6A20 solute carrier family 6 member 20 3p21.31 5.21 4.9 5.05 2.79 2.61 37.347 30.556 none 0 0 HHIP hedgehog interacting protein 4q31.21 5.37 4.33 4.85 6.19 5.05 70.39 34.039 none 0 3 CATSPERB catsper channel auxiliary subunit beta 14q32.12 6.41 3.24 4.83 6.23 3.09 53.731 8.454 none 0 0 INHBE inhibin subunit beta E Vesicles 12q13.3 5.72 3.79 4.75 2.45 1.46 32.174 9.857 review 2 98 DOK5 docking protein 5 Plasma membrane 20q13.2 4.61 4.66 4.63 3.3 3.34 209.593 220.178 review 10 0 ESM1 endothelial cell specific molecule 1 Vesicles 5q11.2 4.31 4.93 4.62 0.97 1.28 41.971 67.655 none 0 10 PABPC4L poly(A) binding protein cytoplasmic 4 like 4q28.3 5.46 3.58 4.52 2.92 1.76 17.107 6.905 none 0 0 PGAM4 phosphoglycerate mutase family member 4 Nucleus Xq21.1 4.29 4.63 4.46 0.94 1.08 0.687 0.746 none 0 0 R3HDML R3H domain containing like Nucleus;Cytosol 20q13.12 3.89 4.88 4.38 1.02 1.35 0.672 0.889 none 0 0 HS3ST3A1 heparan sulfate-glucosamine 3-sulfotransferase 3A1 Cytoskeleton 17p12 4.94 3.7 4.32 3.99 2.92 57.271 23.272 none 0 0 TRIM67 tripartite motif containing 67 1q42.2 4.74 3.88 4.31 5.52 4.55 14.684 8.95 none 0 0 PIRT phosphoinositide interacting regulator of transient receptor potential channels 17p12 3.94 4.6 4.27 7.26 8.37 28.608 47.655 none 0 3 TDO2 tryptophan 2,3-dioxygenase Plasma membrane;Cytosol;Cytoskeleton 4q32.1 3.49 4.99 4.24 1.66 2.65 19.253 62.866 pathway review 7 1 CEP162 centrosomal protein 162 Nucleus 6q14.2-q14.3 4.93 3.49 4.21 5.37 3.79 114.425 47.255 none 0 0 MEX3A mex-3 RNA binding family member A Cytosol 1q22 5.03 3.33 4.18 0.71 0.14 13.607 6.111 none 0 0 HMGA2 high mobility group AT-hook 2 Nucleus 12q14.3 3.53 4.69 4.11 1.44 2.08 8.415 17.326 none 0 9 ACSM3 acyl-CoA synthetase medium chain family member 3 16p12.3 4.28 3.9 4.09 3.05 2.71 143.897 100.292 none 0 1 C8orf48 chromosome 8 open reading frame 48 Nucleus;Cytosol 8p22 4.38 3.72 4.05 3.66 3.11 27.267 18.199 none 0 0 PON3 paraoxonase 3 7q21.3 4.16 3.89 4.03 3.39 3.18 235.844 179.812 none 0 0 ZNF556 zinc finger protein 556 Nucleus 19p13.3 4.73 3.32 4.03 2.26 1.48 3.714 2.105 none 0 0 RPEL1 ribulose-5-phosphate-3-epimerase like 1 Plasma membrane;Nucleus;Cytosol 10q24.33 3.51 4.42 3.96 1.81 2.45 0.258 0.326 none 0 2 SLITRK6 SLIT and NTRK like family member 6 Plasma membrane 13q31.1 4.17 3.72 3.95 2.55 2.26 45.008 31.65 surface review 1 0 SKIL SKI like proto-oncogene Nucleus;Cytosol 3q26.2 4.79 3.07 3.93 2.82 1.42 222.72 73.934 none 0 2 CDC16 cell division cycle 16 13q34 4.29 3.55 3.92 3.58 2.93 412.462 280.881 none 0 0 LEMD1 LEM domain containing 1 Plasma membrane 1q32.1 4.16 3.63 3.9 1.83 1.53 40.318 26.111 surface none 0 0 CCDC141 coiled-coil domain containing 141 Nucleus 2q31.2 4.48 3.05 3.77 2.55 1.68 7.206 3.565 none 0 0 GJC3 gap junction protein gamma 3 7q22.1 4.2 3.31 3.75 6.11 4.9 151.023 62.835 review 4 0 ZFP37 ZFP37 zinc finger protein Nucleus;Vesicles 9q32 4.36 3.14 3.75 3.41 2.44 14.973 8.345 none 0 0 DRAXIN dorsal inhibitory axon guidance protein 1p36.22 3.87 3.39 3.63 1.93 1.65 3.918 3.148 none 0 0 NPBWR1 neuropeptides B and W receptor 1 8q11.23 3.55 3.55 3.55 1.83 1.829 review 9 0 PLAG1 PLAG1 zinc finger Nucleus;Cytosol;Cytoskeleton 8q12.1 3.67 3.42 3.54 2.97 2.77 29.192 24.615 none 0 0 WNT2 Wnt family member 2 Vesicles 7q31.2 3.53 3.46 3.5 1.6 1.56 15.603 14.855 none 0 3 ZNF268 zinc finger protein 268 Cytosol 12q24.33 3.86 3.08 3.47 1.31 0.69 16.609 11.667 none 0 0 ZNF799 zinc finger protein 799 Nucleus;Cytoskeleton 19p13.2 3.23 3.52 3.38 3.46 3.76 14.623 16.762 none 0 0 TNFSF18 TNF superfamily member 18 1q25.1 3.01 3.66 3.33 0.67 0.96 1.353 1.731 none 0 2 RGPD4 RANBP2 like and GRIP domain containing 4 Nucleus;Vesicles 2q12.3 3.38 3.2 3.29 26.37 25.3 2.966 2.755 none 0 0 PON1 paraoxonase 1 7q21.3 3.42 3.12 3.27 1.55 1.4 14.398 11.519 review 3 63 ZNF214 zinc finger protein 214 Nucleus;Cytoskeleton 11p15.4 3.12 3.28 3.2 1.43 1.53 5.29 5.688 none 0 0 GPR161 G protein-coupled receptor 161 Cytoskeleton 1q24.2 3.07 3.04 3.05 3.13 3.1 48.331 47.076 none 0 1