← All fusions
AZGP1::GJC3 High support
Canonical-transcript structure of the two partner genes, and the read-level evidence
supporting the fusion in each tumor sample.
Known studies
Recorded in the Mitelman Database of Chromosome
Aberrations and Gene Fusions in Cancer in 4 publications (10 reported cases). Reported in:
Adenocarcinoma; Nonneoplastic epithelial disorder/lesion; Schwannoma.
Jung et al 2018 ,
Cancer Lett — Adenocarcinoma (Breast) Babiceanu et al 2016 ,
Nucleic Acids Res — Nonneoplastic epithelial disorder/lesion (Salivary gland, Prostate, Skin, Kidney, Liver, Pancreas, Testis) Agnihotri et al 2016 ,
Nat Genet — Schwannoma (Soft tissue) Nacu et al 2011 ,
BMC Med Genomics — Adenocarcinoma (Prostate)
Canonical transcripts in genomic order
spliced together in the fusion mRNA
37.1 kb apart chr7 GJC3 (-) ENST00000312891 · Ensembl canonical 99,923,603
breakpoint
99,923,266 99,929,620 2 exons · 6.4 kb chr7 AZGP1 (-) ENST00000292401 · Ensembl canonical 99,971,746
breakpoint
99,966,730 99,976,031 4 exons · 9.3 kb
Canonical transcripts shown in genomic order
on chr7 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed
to 1% of their genomic length so the exons are easier to see — the
pixel-space x-axis is therefore non-linear, but the labelled start and
end coordinates of each transcript are exact. The gap shown between
the two panels (when on the same chromosome) is the actual distance
between gene bodies. Transcript IDs are MANE Select where available,
else Ensembl_canonical, else the longest protein-coding transcript.
Left hand (primary) Reportable 457 fragments (289 split, 161 discordant)
· AZGP1 exon 2 → GJC3 exon 2 All 7 candidate breakpoints in this sample Breakpoint (up) Breakpoint (down) Type Junction Total Split Realigned Discordant chr7:99,971,746 chr7:99,923,603 DEL KNOWN/KNOWN 457 289 7 161 chr7:99,971,746 chr7:99,929,621 DEL KNOWN/CANONICAL 205 19 5 181 chr7:99,968,155 chr7:99,929,621 DEL KNOWN/CANONICAL 188 2 0 186 chr7:99,971,746 chr7:99,928,914 DEL KNOWN/CANONICAL 174 2 0 172 chr7:99,968,155 chr7:99,923,603 DEL KNOWN/KNOWN 166 2 0 164 chr7:99,971,741 chr7:99,923,597 DEL UNKNOWN/CANONICAL 147 1 0 146 chr7:99,971,746 chr7:99,923,597 DEL KNOWN/CANONICAL 139 1 0 138
Lung metastasis Reportable 678 fragments (639 split, 25 discordant)
· AZGP1 exon 2 → GJC3 exon 2 All 7 candidate breakpoints in this sample Breakpoint (up) Breakpoint (down) Type Junction Total Split Realigned Discordant chr7:99,971,746 chr7:99,923,603 DEL KNOWN/KNOWN 678 639 14 25 chr7:99,971,746 chr7:99,929,621 DEL KNOWN/CANONICAL 65 17 3 45 chr7:99,968,155 chr7:99,929,621 DEL KNOWN/CANONICAL 51 1 0 50 chr7:99,971,746 chr7:99,928,914 DEL KNOWN/CANONICAL 44 1 1 42 chr7:99,968,155 chr7:99,923,603 DEL KNOWN/KNOWN 32 3 0 29 chr7:99,971,746 chr7:99,923,597 DEL KNOWN/CANONICAL 28 3 0 25 chr7:99,975,945 chr7:99,923,603 DEL KNOWN/KNOWN 2 2 0 0