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CCDC6::MRLN

Known partner

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the CCDC6::MRLN gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 35.3 kb apart chr10 MRLN (-) ENST00000414264 · Ensembl canonical 59,738,562 breakpoint 59,736,692 59,753,455 3 exons · 16.8 kb chr10 CCDC6 (-) ENST00000263102 · Ensembl canonical 59,804,420 breakpoint 59,788,747 59,906,556 9 exons · 117.8 kb
Canonical transcripts shown in genomic order on chr10 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Lung metastasis

Reportable 2 fragments (2 split, 0 discordant) · CCDC6 exon 7 → MRLN exon 2

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