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CTBS::GNG5

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

Recorded in the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer in 4 publications (17 reported cases). Reported in: Adenocarcinoma; Malignant epithelial tumor, special type; Nonneoplastic mesenchymal disorder/lesion; Nonneoplastic hematologic disorder/lesion; Nonneoplastic epithelial disorder/lesion; Schwannoma.

Canonical transcripts in genomic order spliced together in the fusion mRNA 43.0 kb apart chr1 GNG5 (-) ENST00000370645 · Ensembl canonical 84,501,970 breakpoint 84,498,325 84,506,581 4 exons · 8.3 kb chr1 CTBS (-) ENST00000370630 · Ensembl canonical 84,563,257 breakpoint 84,549,611 84,574,440 7 exons · 24.8 kb
Canonical transcripts shown in genomic order on chr1 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 6 fragments (6 split, 0 discordant) · CTBS exon 6 → GNG5 exon 3

Lung metastasis

Reportable 48 fragments (48 split, 0 discordant) · CTBS exon 6 → GNG5 exon 3

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