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DHRS1::RABGGTA

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

Recorded in the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer in 1 publication . Reported in: Adenocarcinoma.

Canonical transcripts in genomic order spliced together in the fusion mRNA 19.0 kb apart chr14 RABGGTA (-) ENST00000216840 · Ensembl canonical 24,271,310 breakpoint 24,265,538 24,271,597 17 exons · 6.1 kb chr14 DHRS1 (-) ENST00000288111 · Ensembl canonical 24,298,614 breakpoint 24,290,598 24,299,780 9 exons · 9.2 kb
Canonical transcripts shown in genomic order on chr14 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Sub-threshold 4 fragments (2 split, 0 discordant)

Lung metastasis

Reportable 107 fragments (107 split, 0 discordant)
All 3 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr14:24,298,614 chr14:24,271,310 DEL UNKNOWN/UNKNOWN 107 107 0 0
chr14:24,292,198 chr14:24,271,310 DEL UNKNOWN/UNKNOWN 17 17 0 0
chr14:24,292,437 chr14:24,271,310 DEL UNKNOWN/UNKNOWN 4 4 0 0

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