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EIF3K::ACTN4

Known partner

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

Recorded in the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer in 2 publications . Reported in: Adenocarcinoma; Transitional cell carcinoma.

Canonical transcripts in genomic order spliced together in the fusion mRNA 10.7 kb apart chr19 EIF3K (+) ENST00000248342 · Ensembl canonical 38,635,118 breakpoint 38,619,188 38,636,954 8 exons · 17.8 kb chr19 ACTN4 (+) ENST00000252699 · Ensembl canonical 38,700,600 breakpoint 38,647,649 38,731,589 21 exons · 83.9 kb
Canonical transcripts shown in genomic order on chr19 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 4 fragments (2 split, 2 discordant) · EIF3K exon 7 → ACTN4 exon 2
All 2 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr19:38,635,118 chr19:38,700,600 DEL KNOWN/KNOWN 4 2 0 2
chr19:38,632,496 chr19:38,700,600 DEL KNOWN/KNOWN 1 1 0 0

Lung metastasis

Sub-threshold 1 fragments (1 split, 0 discordant) · EIF3K exon 7 → ACTN4 exon 2

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