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EWSR1::KLF15

Known partner

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

Recorded in the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer in 4 publications . Reported in: Myoepithelioma/myoepithelial carcinoma/mixed tumor; Malignant epithelial tumor, special type.

Canonical transcripts in genomic order spliced together in the fusion mRNA chr22 EWSR1 (+) ENST00000397938 · Ensembl canonical 29,291,599 breakpoint 29,268,268 29,300,521 17 exons · 32.3 kb chr3 KLF15 (-) ENST00000296233 · Ensembl canonical 126,352,947 breakpoint 126,342,635 126,357,408 3 exons · 14.8 kb
Canonical transcripts shown in genomic order — EWSR1 on chr22, KLF15 on chr3. Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 35 fragments (2 split, 33 discordant) · EWSR1 exon 8 → KLF15 exon 2
All 4 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr22:29,291,599 chr3:126,352,947 BND KNOWN/KNOWN 35 2 0 33
chr22:29,288,786 chr3:126,352,947 BND KNOWN/KNOWN 34 2 0 32
chr22:29,287,134 chr3:126,352,947 BND KNOWN/KNOWN 17 5 0 12
chr22:29,288,786 chr3:126,352,508 BND KNOWN/CANONICAL 1 1 0 0

Lung metastasis

Sub-threshold 6 fragments (5 split, 1 discordant)

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