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KANSL1::ARL17A

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

Recorded in the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer in 6 publications (16 reported cases). Reported in: Carcinoma, NOS; Chronic myeloid leukemia, t(9;22); Adenocarcinoma; Osteosarcoma, NOS; Embryonal rhabdomyosarcoma; Wilms tumor; Primitive neuroectodermal tumor/Medulloblastoma; Ependymoma; Astrocytoma, grade III-IV/Glioblastoma; Nonneoplastic epithelial disorder/lesion; Nonneoplastic hematologic disorder/lesion; Acute lymphoblastic leukemia/lymphoblastic lymphoma.

Canonical transcripts in genomic order spliced together in the fusion mRNA 359.3 kb apart chr17 KANSL1 (-) ENST00000432791 · Ensembl canonical 46,094,560 breakpoint 46,029,916 46,193,429 15 exons · 163.5 kb chr17 ARL17A (-) ENST00000336125 · Ensembl canonical 46,570,869 breakpoint 46,552,756 46,579,691 4 exons · 26.9 kb
Canonical transcripts shown in genomic order on chr17 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 84 fragments (3 split, 4 discordant) · KANSL1 exon 3 → ARL17A exon 3

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