Sebas · MEC

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LRRC37A::LRRC37A2

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the LRRC37A::LRRC37A2 gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 174.7 kb apart chr17 LRRC37A (+) ENST00000320254 · Ensembl canonical 46,337,729 breakpoint 46,295,131 46,337,794 14 exons · 42.7 kb chr17 LRRC37A2 (+) ENST00000576629 · Ensembl canonical 46,548,625 breakpoint 46,512,468 46,555,646 14 exons · 43.2 kb
Canonical transcripts shown in genomic order on chr17 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 58 fragments (4 split, 53 discordant) · LRRC37A exon 10 → LRRC37A2 exon 8
All 8 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr17:46,332,656 chr17:46,546,255 DEL KNOWN/KNOWN 58 4 1 53
chr17:46,331,981 chr17:46,523,084 DEL KNOWN/KNOWN 49 1 0 48
chr17:46,332,656 chr17:46,548,312 DEL KNOWN/KNOWN 44 1 0 43
chr17:46,323,027 chr17:46,520,212 DEL KNOWN/KNOWN 28 4 3 21
chr17:46,306,309 chr17:46,520,212 DEL KNOWN/KNOWN 25 17 0 8
chr17:46,306,309 chr17:46,517,362 DEL KNOWN/KNOWN 21 9 2 10
chr17:46,323,027 chr17:46,540,176 DEL KNOWN/KNOWN 17 9 2 6
chr17:46,331,768 chr17:46,548,659 DEL UNKNOWN/UNKNOWN 17 1 0 16

Lung metastasis

Sub-threshold 61 fragments (1 split, 57 discordant) · LRRC37A exon 13 → LRRC37A2 exon 9
All 7 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr17:46,337,729 chr17:46,548,625 DEL UNKNOWN/UNKNOWN 61 1 3 57
chr17:46,334,182 chr17:46,552,040 DEL UNKNOWN/UNKNOWN 4 4 0 0
chr17:46,329,293 chr17:46,547,163 DEL UNKNOWN/UNKNOWN 3 3 0 0
chr17:46,328,197 chr17:46,546,009 DEL UNKNOWN/UNKNOWN 2 2 0 0
chr17:46,331,257 chr17:46,549,042 DEL UNKNOWN/UNKNOWN 2 1 0 1
chr17:46,329,293 chr17:46,547,165 DEL UNKNOWN/UNKNOWN 2 2 0 0
chr17:46,329,293 chr17:46,547,162 DEL UNKNOWN/UNKNOWN 2 2 0 0

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