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MAG::CD22

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the MAG::CD22 gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 15.4 kb apart chr19 MAG (+) ENST00000392213 · Ensembl canonical 35,312,017 breakpoint 35,292,161 35,313,807 11 exons · 21.6 kb chr19 CD22 (+) ENST00000085219 · Ensembl canonical 35,329,189 breakpoint 35,329,187 35,347,361 14 exons · 18.2 kb
Canonical transcripts shown in genomic order on chr19 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 95 fragments (62 split, 32 discordant) · MAG exon 10 → CD22 exon 2
All 5 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr19:35,312,017 chr19:35,329,189 DEL KNOWN/CANONICAL 95 62 1 32
chr19:35,313,429 chr19:35,329,189 DEL CANONICAL/KNOWN 33 3 1 29
chr19:35,312,325 chr19:35,329,189 DEL KNOWN/KNOWN 28 1 0 27
chr19:35,310,643 chr19:35,329,189 DEL KNOWN/KNOWN 23 8 1 14
chr19:35,310,643 chr19:35,329,182 DEL KNOWN/UNKNOWN 16 1 0 15

Lung metastasis

Reportable 3 fragments (2 split, 1 discordant)
All 2 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr19:35,313,429 chr19:35,329,189 DEL CANONICAL/KNOWN 3 2 0 1
chr19:35,312,017 chr19:35,329,189 DEL KNOWN/KNOWN 1 1 0 0

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