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PAOX::MTG1

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the PAOX::MTG1 gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 2.5 kb apart chr10 PAOX (+) ENST00000278060 · Ensembl canonical 133,391,428 breakpoint 133,379,262 133,391,694 7 exons · 12.4 kb chr10 MTG1 (+) ENST00000317502 · Ensembl canonical 133,395,713 breakpoint 133,394,157 133,422,520 11 exons · 28.4 kb
Canonical transcripts shown in genomic order on chr10 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 52 fragments (30 split, 22 discordant) · PAOX exon 7 → MTG1 exon 2
All 4 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr10:133,391,428 chr10:133,395,713 DEL CANONICAL/KNOWN 52 30 0 22
chr10:133,391,491 chr10:133,395,713 DEL CANONICAL/KNOWN 41 17 0 24
chr10:133,391,430 chr10:133,395,713 DEL CANONICAL/KNOWN 23 1 0 22
chr10:133,389,747 chr10:133,395,713 DEL KNOWN/KNOWN 16 8 1 7

Lung metastasis

Reportable 4 fragments (4 split, 0 discordant) · PAOX exon 7 → MTG1 exon 3
All 3 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr10:133,391,428 chr10:133,395,713 DEL CANONICAL/CANONICAL 4 4 0 0
chr10:133,391,491 chr10:133,395,713 DEL CANONICAL/CANONICAL 2 2 0 0
chr10:133,389,747 chr10:133,395,713 DEL KNOWN/KNOWN 1 1 0 0

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