← All fusions

POLR2J2::UPK3BL1

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the POLR2J2::UPK3BL1 gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 23.3 kb apart chr7 UPK3BL1 (-) ENST00000340457 · Ensembl canonical 102,640,773 breakpoint 102,637,025 102,642,791 6 exons · 5.8 kb chr7 POLR2J2 (-) ENST00000333432 · Ensembl canonical 102,666,077 breakpoint 102,666,046 102,671,663 4 exons · 5.6 kb
Canonical transcripts shown in genomic order on chr7 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 54 fragments (24 split, 30 discordant) · POLR2J2 exon 4 → UPK3BL1 exon 2
All 3 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr7:102,666,077 chr7:102,640,773 DEL CANONICAL/KNOWN 54 24 0 30
chr7:102,668,915 chr7:102,640,773 DEL KNOWN/KNOWN 20 2 0 18
chr7:102,666,077 chr7:102,640,414 DEL CANONICAL/KNOWN 10 1 2 7

Contact Us

Please contact us with any questions or comments.