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SMURF2P1::LRRC37BP1

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the SMURF2P1::LRRC37BP1 gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 13.7 kb apart chr17 SMURF2P1 (+) ENST00000514992 · Ensembl canonical 30,610,942 breakpoint 30,600,865 30,615,980 5 exons · 15.1 kb chr17 LRRC37BP1 (+) ENST00000398851 · Ensembl canonical 30,631,755 breakpoint 30,629,680 30,637,302 5 exons · 7.6 kb
Canonical transcripts shown in genomic order on chr17 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Left hand (primary)

Reportable 62 fragments (37 split, 25 discordant) · SMURF2P1 exon 4 → LRRC37BP1 exon 2
All 5 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr17:30,610,942 chr17:30,631,755 DEL KNOWN/KNOWN 62 37 0 25
chr17:30,610,942 chr17:30,629,680 DEL KNOWN/KNOWN 28 2 0 26
chr17:30,610,942 chr17:30,631,737 DEL KNOWN/CANONICAL 27 1 0 26
chr17:30,610,929 chr17:30,631,753 DEL UNKNOWN/UNKNOWN 24 1 0 23
chr17:30,610,942 chr17:30,633,098 DEL KNOWN/KNOWN 4 3 0 1

Lung metastasis

Reportable 61 fragments (58 split, 3 discordant) · SMURF2P1 exon 4 → LRRC37BP1 exon 2
All 2 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr17:30,610,942 chr17:30,631,755 DEL KNOWN/KNOWN 61 58 0 3
chr17:30,610,942 chr17:30,629,680 DEL KNOWN/KNOWN 4 1 0 3

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