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ZNF224::ZNF225

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the ZNF224::ZNF225 gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 3.6 kb apart chr19 ZNF224 (+) ENST00000693561 · Ensembl canonical 44,108,337 breakpoint 44,094,361 44,109,826 6 exons · 15.5 kb chr19 ZNF225 (+) ENST00000262894 · Ensembl canonical 44,112,822 breakpoint 44,113,399 44,134,822 5 exons · 21.4 kb
Canonical transcripts shown in genomic order on chr19 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Lung metastasis

Reportable 47 fragments (45 split, 2 discordant)
All 2 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr19:44,108,337 chr19:44,112,822 DEL UNKNOWN/UNKNOWN 47 45 0 2
chr19:44,107,264 chr19:44,131,719 DEL UNKNOWN/UNKNOWN 3 3 0 0

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