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ZNF443::ZNF799

High support

Canonical-transcript structure of the two partner genes, and the read-level evidence supporting the fusion in each tumor sample.

Known studies

No published studies in the Mitelman database describe the ZNF443::ZNF799 gene fusion. It may be novel, private to this case, or a technical artifact — absence from a curated database is not by itself evidence either way.

Canonical transcripts in genomic order spliced together in the fusion mRNA 28.4 kb apart chr19 ZNF799 (-) ENST00000430385 · Ensembl canonical 12,393,423 breakpoint 12,390,016 12,401,271 4 exons · 11.3 kb chr19 ZNF443 (-) ENST00000301547 · Ensembl canonical 12,430,320 breakpoint 12,429,706 12,441,021 4 exons · 11.3 kb
Canonical transcripts shown in genomic order on chr19 (lower-coordinate gene on the left). Each gene is drawn at its own zoom level. Introns are compressed to 1% of their genomic length so the exons are easier to see — the pixel-space x-axis is therefore non-linear, but the labelled start and end coordinates of each transcript are exact. The gap shown between the two panels (when on the same chromosome) is the actual distance between gene bodies. Transcript IDs are MANE Select where available, else Ensembl_canonical, else the longest protein-coding transcript.

Lung metastasis

Reportable 55 fragments (1 split, 54 discordant) · ZNF443 exon 4 → ZNF799 exon 2
All 4 candidate breakpoints in this sample
Breakpoint (up)Breakpoint (down)TypeJunction TotalSplit RealignedDiscordant
chr19:12,430,320 chr19:12,393,423 DEL CANONICAL/KNOWN 55 1 0 54
chr19:12,430,164 chr19:12,390,741 DEL UNKNOWN/UNKNOWN 22 1 0 21
chr19:12,431,244 chr19:12,391,721 DEL UNKNOWN/UNKNOWN 4 1 0 3
chr19:12,430,736 chr19:12,391,129 DEL UNKNOWN/UNKNOWN 2 1 0 1

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